{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:58:27Z","timestamp":1772639907477,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Age-related atherosclerosis has been shown to cause aortic stiffness and wall rigidification. This analysis aimed to correlate age and dissection extension length in a large contemporary multicentre study. We hypothesize that younger patients suffer more extensive DeBakey type I dissection due to aortic wall integrity, allowing unhindered extension within the layers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The perioperative data of 3385 patients from the German Registry for Acute Aortic Dissection Type A were retrospectively analyzed with regard to postoperative outcomes and dissection extension. Patients with DeBakey type I aortic dissection (n\u2009=\u20092510) were retrospectively identified and divided into 2 age groups for comparison: \u226469\u2009years (n\u2009=\u20091741) and \u226570\u2009years (n\u2009=\u2009769). Patients with DeBakey type II dissection or connective tissue disease were excluded from the analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In younger patients (\u226469\u2009years), aortic dissection involved the supra-aortic vessels significantly more often (52.0% vs 40.1%; P\u2009&amp;lt;\u20090.001) and extended significantly further downstream the aorta: descending aorta (68.4% vs 57.1%; P\u2009&amp;lt;\u20090.001), abdominal aorta (54.6% vs 42.1%; P\u2009&amp;lt;\u20090.001) and iliac bifurcation (36.6% vs 26.0%; P\u2009&amp;lt;\u20090.001). Consequently, younger patients also presented with significantly higher incidences of preoperative cerebral (P\u2009&amp;lt;\u20090.001), spinal (P\u2009&amp;lt;\u20090.001), visceral (P\u2009&amp;lt;\u20090.001), renal (P\u2009=\u20090.013) and peripheral (P\u2009&amp;lt;\u20090.001) malperfusion. In older patients (\u226570\u2009years), dissection extent was significantly more often limited to the level of the aortic arch (40.9% vs 29.2%; P\u2009&amp;lt;\u20090.001). No significant difference was found with regard to 30-day mortality (20.7% vs 23.6%; P\u2009=\u20090.114).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Extensive DeBakey type I aortic dissection is less frequent in older patients \u226570\u2009years than in younger patients. In contrast, younger patients suffer more often from preoperative organ malperfusion and associated complications. Postoperative mortality remains high irrespective of age groups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad175","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T20:08:30Z","timestamp":1682626110000},"source":"Crossref","is-referenced-by-count":7,"title":["The correlation of age and extension length in DeBakey type I aortic dissection: are older patients over 70 years at a lower risk?"],"prefix":"10.1093","volume":"63","author":[{"given":"Julia","family":"Merkle-Storms","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart Center, University of Cologne , Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-3330","authenticated-orcid":false,"given":"Christopher","family":"Gaisendrees","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Heart Center, University of Cologne , Cologne, 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Cardiac Surgery, University Hospital, LMU Munich , Munich, Germany"},{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance , Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-4994","authenticated-orcid":false,"given":"Mario","family":"Lescan","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Medical Center , Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Brickwede","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Aortic Center Hamburg, University Heart and Vascular Center Hamburg , Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Poeling","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Schuechtermann Clinic , Bad Rothenfelde, 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