{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:52:01Z","timestamp":1788537121496,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL119857-01A1"],"award-info":[{"award-number":["R01HL119857-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p\/><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Rapid diameter growth is a criterion for ascending thoracic aortic aneurysm repair; however, there are sparse data on aneurysm elongation rate. The purpose of this study was to assess aortic elongation rates in nonsyndromic, nonsurgical aneurysms to understand length dynamics and correlate with aortic diameter over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients with &amp;lt;5.5-cm aneurysms and computed tomography angiography imaging at baseline and 3\u20135\u2009years follow-up underwent patient-specific three-dimensional aneurysm reconstruction using MeVisLab. Aortic length was measured along the vessel centreline between the annulus and aortic arch. Maximum aneurysm diameter was determined from imaging in a plane normal to the vessel centreline. Average rates of aneurysm growth were evaluated using the longest available follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Over the follow-up period, the mean aortic length for 67 identified patients increased from 118.2 (95% confidence interval: 115.4\u2013121.1) mm to 120.2 (117.3\u2013123.0) mm (P\u2009=\u20090.02) and 15 patients (22%) experienced a change in length of \u22655% from baseline. The mean annual growth rate for length [0.38 (95% confidence interval: 0.11\u20130.65) mm\/year] was correlated with annual growth rate for diameter [0.1 (0.03\u20130.2) mm\/year] (rho\u2009=\u20090.30, P\u2009=\u20090.01). Additionally, annual percentage change in length [0.3 (0.1\u20130.5)%\/year] was similar to percentage change in diameter [0.2 (0.007\u20130.4)%\/year, P\u2009=\u20090.95].<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Aortic length increases in parallel with aortic diameter at a similar percentage rate. Further work is needed to identify whether elongation rate is associated with dissection risk. Such studies may provide insight into why patients with aortic diameters smaller than surgical guidelines continue to experience dissection events.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejcts\/ezad241","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T19:18:07Z","timestamp":1687634287000},"source":"Crossref","is-referenced-by-count":13,"title":["Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population"],"prefix":"10.1093","volume":"63","author":[{"given":"Arushi","family":"Gulati","sequence":"first","affiliation":[{"name":"Department of Surgery, University of California San Francisco (UCSF) and San Francisco VA Medical Center , San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siavash","family":"Zamirpour","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California San Francisco (UCSF) and San Francisco VA Medical Center , 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