{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:40Z","timestamp":1753876300271,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Central Universities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This study aimed to explore the prognostic disparity among T4N0-2M0 non-small-cell lung cancer (NSCLC) patients with different T4 descriptors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>T3-4N0-2M0 NSCLC patients were included. Patients were assigned to 7 subgroups: T3, T4 tumours with size larger than 70\u2009mm (T4-size), T4 tumours with aorta\/vena cava\/heart invasion (T4-blood vessels), T4 tumours with vertebra invasion (T4-vertebra), T4 tumours with carina\/trachea invasion (T4-carina\/trachea), T4 tumours with additional tumour nodules in different lobes of ipsilateral lung (T4-add) and T4 tumours had at least 2 T4 descriptors (T4-multiple). Univariable and multivariable Cox analyses were used to explore the effect of T4 category on overall survival. Kaplan\u2013Meier method with log-rank test was used to compare survival differences among subgroups. Propensity score matching was used to minimize the bias caused by imbalanced covariates between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 41\u00a0303 eligible T3-4N0-2M0 NSCLC cases were included (17\u00a0057 T3 cases and 24\u00a0246 T4 cases). There were 10\u00a0682 cases, 573 cases, 557 cases, 64 cases, 2888 cases and 9482 cases in the T4-size, T4-blood vessels, T4-vertebra, T4-carina\/trachea, T4-add and T4-multiple subgroups, respectively. Multivariable Cox analyses revealed that T4-add patients had the best prognosis in the entire cohort and in several subgroups. In the matched cohort of T4-add and T4-size and T4-add and T3, the survival of T4-add patients was superior to that of T4-size patients (P\u2009&amp;lt;\u20090.001) but was comparable to that of T3 patients (P\u2009=\u20090.115).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Among NSCLC patients with different T4 descriptors, T4-add patients had the best prognosis. T4-add patients and T3 patients had similar survivals. Herein, we proposed that T4-add patients should be downstaged from T4 to T3 category. Our results served as a novel supplement to the proposals for the T category revision.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad243","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:31:15Z","timestamp":1688563875000},"source":"Crossref","is-referenced-by-count":3,"title":["Investigation of the non-size-determined T4N0-2M0 non-small-cell lung cancer: what is the proper T category for the tumour with additional nodules in different lobes of ipsilateral lung?"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-7159","authenticated-orcid":false,"given":"Jing-Sheng","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Peking University People\u2019s Hospital , Beijing, China"},{"name":"Thoracic Oncology Institute, Peking University People\u2019s Hospital , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Peking University People\u2019s Hospital , Beijing, China"},{"name":"Thoracic Oncology Institute, Peking University People\u2019s Hospital , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Peking University People\u2019s Hospital , Beijing, China"},{"name":"Thoracic Oncology Institute, Peking University People\u2019s Hospital , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Peking University People\u2019s Hospital , Beijing, China"},{"name":"Thoracic Oncology Institute, Peking University People\u2019s Hospital , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"2023070505170413800_ezad243-B1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC Lung Cancer Staging Project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J Thorac Oncol"},{"key":"2023070505170413800_ezad243-B2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1097\/JTO.0000000000000559","article-title":"The IASLC Lung Cancer Staging Project: proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung cancer","volume":"10","author":"Rami-Porta","year":"2015","journal-title":"J Thorac Oncol"},{"key":"2023070505170413800_ezad243-B3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/a-1209-3668","article-title":"Prognostic factors and survival in resected T4 non-small cell lung cancer: is there any difference in the T4 subgroups?","volume":"146","author":"Aksoy","year":"2021","journal-title":"Zentralbl Chir"},{"key":"2023070505170413800_ezad243-B4","doi-asserted-by":"crossref","first-page":"17588359221130502","DOI":"10.1177\/17588359221130502","article-title":"Reconsidering T component of cancer staging for T3\/T4 non-small-cell lung cancer with additional nodule","volume":"14","author":"Wang","year":"2022","journal-title":"Ther Adv Med Oncol"},{"key":"2023070505170413800_ezad243-B5","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.ejso.2021.07.012","article-title":"Should we distinguish between intra and extrapericardial pulmonary artery involvement in NSCLC? A multicenter retrospective case-control study","volume":"47","author":"Campisi","year":"2021","journal-title":"Eur J Surg Oncol"},{"key":"2023070505170413800_ezad243-B6","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/ejcts\/ezy360","article-title":"T4 extension alone is more predictive of better survival than a tumour size &gt;7 cm for resected T4N0-1M0 non-small-cell lung cancer","volume":"55","author":"Li","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023070505170413800_ezad243-B7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav Res"},{"key":"2023070505170413800_ezad243-B8","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezac558","article-title":"?","author":"Cai","year":"2023","journal-title":"Eur J Cardiothorac Surg"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/64\/1\/ezad243\/50801063\/ezad243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/64\/1\/ezad243\/50801063\/ezad243.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:31:35Z","timestamp":1688563895000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/doi\/10.1093\/ejcts\/ezad243\/7204425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezad243","relation":{},"ISSN":["1873-734X"],"issn-type":[{"type":"electronic","value":"1873-734X"}],"subject":[],"published-other":{"date-parts":[[2023,7,1]]},"published":{"date-parts":[[2023,6,21]]},"article-number":"ezad243"}}