{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:50:43Z","timestamp":1785340243259,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The Carpentier Perimount (CP) Magna Ease, the Crown Phospholipid Reduction Treatment (PRT) and the Trifecta bovine pericardial valves have been widely used worldwide. The primary end point of this study was to compare the haemodynamic performance quantified by in vivo echocardiograms of these 3 aortic prostheses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>The \u201cBEST-VALVE\u201d (comparison of 3 contemporary cardiac bioprostheses: mid-term valve haemodynamic performance) was a single-centre randomized clinical trial to compare the haemodynamic and clinical outcomes of the aforementioned bioprostheses. The 5-year results are assessed in this manuscript.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 154 patients were included. The CP Magna Ease (n\u2009=\u200948, 31.2%), Crown PRT (n\u2009=\u200951, 32.1%) and Trifecta (n\u2009=\u200955, 35.7%) valves were compared. Significant differences were observed among the 3 bioprostheses 5 years after the procedure. The following haemodynamic differences were found between the CP Magna Ease and the Crown PRT bioprostheses [mean aortic gradient: 12.3 mmHg (interquartile range {IQR} 7.8\u201317.5) for the CP Magna Ease vs 15\u2009mmHg (IQR 10.8\u201331.9) for the Crown PRT, P\u2009&amp;lt;\u20090.001] and between the CP Magna Ease and the Trifecta prostheses [mean aortic gradient: 12.3 mmHg (IQR 7.8\u201317.5) for the CP Magna Ease vs 14.7\u2009mmHg (IQR 8.2\u201355) for the Trifecta, P\u2009&amp;lt;\u20090.001], with a better haemodynamic performance of the CP Magna Ease. The cumulative incidence of severe structural valve degeneration was 9.5% in the Trifecta group at 6\u2009years of follow-up. The 1-, 3- and 5-year survival from all-cause mortality was 91.5%, 83.5% and 74.8%, respectively (log rank P\u2009=\u20090.440). Survival from the composite event at the 1-, 3- and 5-year follow-up was 92.8%, 74.6% and 59%, respectively (log rank P\u2009=\u20090.299).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>We detected significant differences between the 3 bioprostheses; the CP Magna Ease had the best haemodynamic performance at the 5-year follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad261","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T19:05:33Z","timestamp":1689879933000},"source":"Crossref","is-referenced-by-count":3,"title":["5-Year haemodynamic performance of three aortic bioprostheses. A randomized clinical trial"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-4470","authenticated-orcid":false,"given":"Lourdes","family":"Montero Cruces","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Cl\u00ednico San Carlos Hospital , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Carnero Alc\u00e1zar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Cl\u00ednico San Carlos Hospital , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"P\u00e9rez Camargo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Cl\u00ednico San Carlos Hospital , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cobiella Carnicer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Cl\u00ednico San Carlos Hospital , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Campelos Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Cl\u00ednico San Carlos Hospital , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Jos\u00e9","family":"Reguillo Lacruz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Cl\u00ednico San Carlos Hospital , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Carlos","family":"Maroto Castellanos","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Cl\u00ednico San Carlos Hospital , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"2023083011540995400_ezad261-B1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ejcts\/ezab389","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"60","author":"Vahanian","year":"2021","journal-title":"Eur J Cardio-Thoracic Surg"},{"key":"2023083011540995400_ezad261-B2","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1093\/eurheartj\/ehv580","article-title":"Aortic valve replacement with mechanical vs. biological prostheses in patients aged 50-69 years","volume":"37","author":"Glaser","year":"2016","journal-title":"Eur Heart J"},{"key":"2023083011540995400_ezad261-B3","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.athoracsur.2014.10.070","article-title":"Long-term durability of bioprosthetic aortic valves: implications from 12,569 implants","volume":"99","author":"Johnston","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"2023083011540995400_ezad261-B4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-0038-1676853","article-title":"Clinical Short-Term Outcome and Hemodynamic Comparison of Six Contemporary Bovine Aortic Valve Prostheses","volume":"68","author":"Hartrumpf","year":"2020","journal-title":"Thorac Cardiovasc Surg"},{"key":"2023083011540995400_ezad261-B5","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1055\/s-0038-1660517","article-title":"Hemodynamic Results and Mid-term Follow-up of 850 19 to 23 mm Perimount Magna Ease Valves","volume":"67","author":"Anselmi","year":"2019","journal-title":"Thorac Cardiovasc Surg"},{"key":"2023083011540995400_ezad261-B6","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.athoracsur.2018.10.063","article-title":"Trifecta Aortic Bioprosthesis: midterm Results in 1,953 Patients From a Single Center","volume":"107","author":"Kilic","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"2023083011540995400_ezad261-B7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1055\/s-0035-1548744","article-title":"Matched Comparison of Two Different Biological Prostheses for Complete Supra-annular Aortic Valve Replacement","volume":"63","author":"Fiegl","year":"2015","journal-title":"Thorac Cardiovasc Surg"},{"key":"2023083011540995400_ezad261-B8","first-page":"1","article-title":"One-year hemodynamic performance of three cardiac aortic bioprostheses: a randomized comparative clinical trial","volume":"10","author":"Montero","year":"2021","journal-title":"J Clin Med"},{"key":"2023083011540995400_ezad261-B9","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/ejcts\/ezx244","article-title":"Standardized definitions of structural deterioration and valve failure in assessing long-term durability of transcatheter and surgical aortic bioprosthetic valves: a consensus statement from the European Association of Percutaneous Cardiovascular Interven","volume":"52","author":"Capodanno","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023083011540995400_ezad261-B10","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.jtcvs.2020.11.181","article-title":"Similar long-term survival after isolated bioprosthetic versus mechanical aortic valve replacement: a propensity-matched analysis","volume":"164","author":"Attia","year":"2022","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023083011540995400_ezad261-B11","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.21037\/jtd-19-3586","article-title":"Bioprosthetic or mechanical heart valves: prosthesis choice for borderline patients?-Results from 9,616 cases recorded in Polish national cardiac surgery registry","volume":"12","author":"Bartus","year":"2020","journal-title":"J Thorac Dis"},{"key":"2023083011540995400_ezad261-B12","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/icvts\/ivaa306","article-title":"Biological versus mechanical aortic valve replacement in non-elderly patients: a single-centre analysis of clinical outcomes and quality of life","volume":"32","author":"Stocco","year":"2021","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2023083011540995400_ezad261-B13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/ejcts\/ezv493","article-title":"Randomized comparison of exercise haemodynamics of Freestyle, Magna Ease and Trifecta bioprostheses after aortic valve replacement for severe aortic stenosis","volume":"50","author":"Bach","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023083011540995400_ezad261-B14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/icvts\/ivab205","article-title":"Mid-term clinical and haemodynamic results after aortic valve replacement with the Trifecta bioprosthesis","volume":"34","author":"Mortel\u00e9","year":"2022","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2023083011540995400_ezad261-B15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.athoracsur.2019.05.073","article-title":"Early First-Generation Trifecta Valve Failure: a Case Series and a Review of the Literature","volume":"109","author":"Kaneyuki","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"2023083011540995400_ezad261-B16","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.athoracsur.2019.06.032","article-title":"Early Structural Valve Degeneration of Trifecta Bioprosthesis","volume":"109","author":"Fukuhara","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"2023083011540995400_ezad261-B17","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1177\/02184923221100994","article-title":"Trifecta versus Perimount Magna Ease aortic valves: failure mechanisms","volume":"30","author":"Suzuki","year":"2022","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"2023083011540995400_ezad261-B18","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/jocs.13953","article-title":"Early structural valve deterioration and reoperation associated with the mitroflow aortic valve","volume":"33","author":"Axtell","year":"2018","journal-title":"J Card Surg"},{"key":"2023083011540995400_ezad261-B19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/ejcts\/ezx117","article-title":"Ten-year results of aortic valve replacement with first-generation Mitroflow bioprosthesis: is early degeneration a structural or a technical issue?","volume":"52","author":"Lootens","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"2023083011540995400_ezad261-B20","first-page":"87","article-title":"Early Hemodynamic Performance of the Crown PRT Aortic Prosthesis: a Prospective Study","volume":"27","author":"Duggan","year":"2018","journal-title":"J Heart Valve Dis"},{"key":"2023083011540995400_ezad261-B21","doi-asserted-by":"crossref","first-page":"107373","DOI":"10.1016\/j.carpath.2021.107373","article-title":"The pathology of early failure in Microflow pericardial valve bioprosthesis (12A\/LX)","volume":"55","author":"Della Barbera","year":"2021","journal-title":"Cardiovasc Pathol"},{"key":"2023083011540995400_ezad261-B22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/icvts\/ivz277","article-title":"An in vitro comparison of internally versus externally mounted leaflets in surgical aortic bioprostheses","volume":"30","author":"Vriesendorp","year":"2020","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2023083011540995400_ezad261-B23","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jtcvs.2013.05.045","article-title":"The new St Jude Trifecta versus Carpentier-Edwards Perimount Magna and Magna Ease aortic bioprosthesis: is there a hemodynamic superiority?","volume":"147","author":"Wendt","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023083011540995400_ezad261-B24","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13019-021-01506-x","article-title":"Long-term survival after Carpentier-Edwards Perimount aortic valve replacement in Western Denmark: a multi-centre observational study","volume":"16","author":"Krasniqi","year":"2021","journal-title":"J Cardiothorac Surg"},{"key":"2023083011540995400_ezad261-B25","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1111\/jocs.15062","article-title":"Six-year follow-up of aortic valve reoperation rates: carpentier-Edwards Perimount versus St. Jude Medical Trifecta","volume":"35","author":"Stubeda","year":"2020","journal-title":"J Card Surg"},{"key":"2023083011540995400_ezad261-B26","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1111\/jocs.15972","article-title":"Trifecta versus perimount bioprosthesis for surgical aortic valve replacement; systematic review and meta-analysis","volume":"36","author":"Yokoyama","year":"2021","journal-title":"J Card Surg"},{"key":"2023083011540995400_ezad261-B27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1055\/s-0038-1637011","article-title":"Randomized (CO) mparison of (TRI) fecta and (P) erimount Magna Ease Supraannular Aortic","volume":"67","author":"Van Linden","year":"2019","journal-title":"Thorac Cardiovasc Surg"},{"key":"2023083011540995400_ezad261-B28","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jtcvs.2021.12.047","article-title":"Structural valve degeneration of bioprosthetic aortic valves: A network meta-analysis","volume":"166","author":"Squiers","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2023083011540995400_ezad261-B29","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/eurheartj\/ehaa799","article-title":"Valve Academic Research Consortium 3: updated end point definitions for aortic valve clinical research","volume":"42","author":"G\u00e9nereux","year":"2021","journal-title":"Eur Heart J"},{"key":"2023083011540995400_ezad261-B30","first-page":"274","article-title":"Durabilidad de la biopr\u00f3tesis TrifectaTM a medio plazo: experiencia de un centro","volume":"29","author":"Montero","year":"2022","journal-title":"Cir Cardiovasc"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezad261\/50918245\/ezad261.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/64\/2\/ezad261\/51305125\/ezad261.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/64\/2\/ezad261\/51305125\/ezad261.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T11:54:35Z","timestamp":1693396475000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/doi\/10.1093\/ejcts\/ezad261\/7227074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,20]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezad261","relation":{},"ISSN":["1873-734X"],"issn-type":[{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8,1]]},"published":{"date-parts":[[2023,7,20]]},"article-number":"ezad261"}}