{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T17:09:48Z","timestamp":1774717788066,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to develop a method to quantify the peel force in an in vitro model simulating repair of ascending aortic dissections with tissue glue (Bioglue).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This study adapted an adhesive T-Peel test for the determination of the peel strength of adhesives by measuring the peeling force of a T-shaped bonded tissue. Measurements were performed on iatrogenic dissected ascending porcine aorta, which has been repaired with Bioglue using different pressure levels. Four conditions were tested: zero sample pressure according to the manufacturer\u2019s recommendation (n\u2009=\u200910), low (504\u2009Pa; n\u2009=\u200911), moderate pressure (1711\u2009Pa; n\u2009=\u200924) and pressure applied by a round shaped vascular \u2018Borst clamp\u2019 (1764\u2009Pa; n\u2009=\u200923). Non-parametric one-way analysis of variance was applied for statistical significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The median peel force (lower quartile, upper quartile) of aortic samples increased depending on the applied pressure: [no pressure 0.030\u2009N\/mm (0.016, 0.057), low pressure 0.040\u2009N\/mm (0.032, 0.070) and moderate pressure 0.214\u2009N\/mm (0.050, 0.304)]. Samples pressurized with the Borst clamp reached 0.078\u2009N\/mm (0.046, 0.152), which was comparable to the peel force of the unpeeled controls [0.107\u2009N\/mm (0.087, 0.124)]. Compared to samples without pressure, Bioglue with the application of the Borst clamp (P\u2009=\u20090.021) and with moderate pressure (P\u2009=\u20090.0007) performed significantly better.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The novel T-Peel test offers an attractive method to test tissue glues in defined in vitro environments. Bioglue peel force increased with pressure on the aortic sample in contrast to low or no pressure as per the manufacturer\u2019s recommendation. Modifying current recommended use may aid in increasing effectiveness of this approach.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad270","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T20:16:44Z","timestamp":1690575404000},"source":"Crossref","is-referenced-by-count":4,"title":["How to test adhesive strength: a biomechanical testing for aortic glue used in type a dissection repair"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1915-0618","authenticated-orcid":false,"given":"Alicja","family":"Zientara","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Royal Brompton Hospital, Part of Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Tsan","family":"Tseng","sequence":"additional","affiliation":[{"name":"Magdi Yacoub Institute , Harefield, UK"},{"name":"National Heart and Lung 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