{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:52:46Z","timestamp":1789573966723,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>To support clinical decision-making in children with aortic valve disease, by compiling the available evidence on outcome after paediatric aortic valve repair (AVr).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A systematic review of literature reporting clinical outcome after paediatric AVr (mean age at surgery &amp;lt;18\u2009years) published between 1 January 1990 and 23 December 2021 was conducted. Early event risks, late event rates and time-to-event data were pooled. A microsimulation model was employed to simulate the lives of individual children, infants and neonates following AVr.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Forty-one publications were included, encompassing 2 623 patients with 17\u00a0217 patient-years of follow-up (median follow-up: 7.3\u2009years; range: 1.0\u201314.4 years). Pooled mean age during repair for aortic stenosis in children (&amp;lt;18 years), infants (&amp;lt;1 year) or neonates (&amp;lt;30 days) was 5.2\u2009\u00b1\u20093.9\u2009years, 35\u2009\u00b1\u2009137\u2009days and 11\u2009\u00b1\u20096\u2009days, respectively. Pooled early mortality after stenosis repair in children, infants and neonates, respectively, was 3.5% (95% confidence interval: 1.9\u20136.5%), 7.4% (4.2\u201313.0%) and 10.7% (6.8\u201316.9%). Pooled late reintervention rate after stenosis repair in children, infants and neonates, respectively, was 3.31%\/year (1.66\u20136.63%\/year), 6.84%\/year (3.95\u201311.83%\/year) and 6.32%\/year (3.04\u201313.15%\/year); endocarditis 0.07%\/year (0.03\u20130.21%\/year), 0.23%\/year (0.07\u20130.71%\/year) and 0.49%\/year (0.18\u20131.29%\/year); and valve thrombosis 0.05%\/year (0.01\u20130.26%\/year), 0.15%\/year (0.04\u20130.53%\/year) and 0.19%\/year (0.05\u20130.77%\/year). Microsimulation-based mean life expectancy in the first 20\u2009years for children, infants and neonates with aortic stenosis, respectively, was 18.4\u2009years (95% credible interval: 18.1\u201318.7 years; relative survival compared to the matched general population: 92.2%), 16.8\u2009years (16.5\u201317.0 years; relative survival: 84.2%) and 15.9\u2009years (14.8\u201317.0 years; relative survival: 80.1%). Microsimulation-based 20-year risk of reintervention in children, infants and neonates, respectively, was 75.2% (72.9\u201377.2%), 53.8% (51.9\u201355.7%) and 50.8% (47.0\u201357.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Long-term outcomes after paediatric AVr for stenosis are satisfactory and dependent on age at surgery. Despite a high hazard of reintervention for valve dysfunction and slightly impaired survival relative to the general population, AVr is associated with low valve-related event occurrences and should be considered in children with aortic valve disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad284","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T08:27:28Z","timestamp":1692001648000},"source":"Crossref","is-referenced-by-count":18,"title":["Aortic valve repair in neonates, infants and children: a systematic review, meta-analysis and microsimulation study"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3828-6775","authenticated-orcid":false,"given":"Maximiliaan L","family":"Notenboom","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Erasmus University Medical Centre , Rotterdam, 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