{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:30:31Z","timestamp":1778182231344,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the quality of life (QOL) of children who underwent the arterial switch operation (ASO) for Transposition of Great Arteries in our population and, specifically, to explore early modifiable factors and the influence of parental and socioeconomic factors on the QOL of these children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Cross-sectional study using Paediatric Quality of Life Inventory\u2122 3.0 Cardiac Module was carried out on 3- to 12-year-old children who had undergone ASO between the years 2012\u20132018. Socioeconomic status was calculated using the modified Kuppuswamy scale (2019). Other clinical factors with possible bearing on the outcome were also analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Immediate survival after surgery was 196 out of 208 (94.2%) with an attrition of 19 patients (9.6%) over the follow-up period. Most surviving children (98.9%) had started formal schooling in age-appropriate classes. Two children had severe neuromotor impairment. The median cumulative health-related QOL score of the children was 97.9 (interquartile range 4.2) at 5.6\u2009\u00b1\u20091.27\u2009years of life. The median scores each of the health-related QOL parameters, viz, heart problem symptoms, treatment compliance, perceived physical appearance, treatment-related anxiety, cognitive problems, and communication was 100 with negative skewing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Excellent QOL was observed in most children after ASO with the median total paediatric QOL scores in all domains of 97.9. Social factors did not show a statistically significant influence on the QOL parameters in the current cohort. The gradually declining trend across the age groups emphasizes the need for continued follow-up for early identification of possible correctable factors and initiating intervention to ensure good QOL into teenage and adulthood.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad321","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T16:56:46Z","timestamp":1695142606000},"source":"Crossref","is-referenced-by-count":3,"title":["Paediatric quality of life in toddlers and children who underwent arterial switch operation beyond early neonatal period"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-879X","authenticated-orcid":false,"given":"Sowmya","family":"Ramanan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-8076","authenticated-orcid":false,"given":"Arun","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Comprehensive Care Center for Neurodevelopmental Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-9622","authenticated-orcid":false,"given":"Ravi Prasad","family":"Varma","sequence":"additional","affiliation":[{"name":"Achutha Menon Center for Health Sciences, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Gopakumar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinitha K","family":"Viswam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Satheesan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudip Dutta","family":"Baruah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabarinath","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baiju S","family":"Dharan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram, 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