{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:30Z","timestamp":1787008710707,"version":"build-2736575974"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z191100006619093"],"award-info":[{"award-number":["Z191100006619093"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970393"],"award-info":[{"award-number":["81970393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the early and long-term outcomes after total arch replacement (TAR) and frozen elephant trunk (FET) implantation in adult patients \u226430\u2009years with acute type A aortic dissection (ATAAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>All young adult patients (\u226430\u2009years) with ATAAD who underwent TAR and FET between 2009 and 2017 were enrolled. The end points were major organ morbidity and mortality, aortic-related events and reoperation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The mean age of all 83 patients was 25.9 (standard deviation, 3.3) years. The in-hospital mortality was 9.64% (8\/83), and 9 (10.8%) patients required re-exploration for bleeding. The aortic-related events risk was 42.7% (32\/75) and the aortic reoperation risk was 17.3% (13\/75). Overall survival was 85.5% [95% confidence interval (CI), 75.9\u201391.5%] at 5\u2009years and 75.9% (95% CI, 63.3\u201384.7%) at 10\u2009years. The cumulative incidence of aortic-related events was 35% (95% CI, 24\u201347%) at 5\u2009years and 58% (95% CI, 36\u201375%) at 10\u2009years; the cumulative reoperation rate was 15% (95% CI, 7.9\u201324%) at 5\u2009years and 17% (95% CI, 9.2\u201327%) at 10\u2009years. Marfan syndrome significantly increased the aortic-related events (P\u2009=\u20090.036) and reoperation (P\u2009=\u20090.041) risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Despite extensive repair in young ATAAD patients, the late aortic dilatation and reoperation risk remain high. The TAR and FET procedures achieved satisfactory early outcomes and reduced late aortic dilatation and reoperation in young patients compared with other records. Close follow-up and aggressive early reintervention are essential for patients with aortic-related risk factors early in life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad330","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:23:49Z","timestamp":1695745429000},"source":"Crossref","is-referenced-by-count":7,"title":["Early and long-term outcomes of young adult patients \u226430 years old with acute type A aortic dissection"],"prefix":"10.1093","volume":"64","author":[{"given":"Qiang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical University , Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Beijing Aortic Disease Center, Beijing Anzhen Hospital, Capital Medical 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