{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:36:14Z","timestamp":1784709374137,"version":"3.55.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"makeadent.org Ram and Sanjita Kalra Aavishqaar"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of this study was to compare clinical outcomes of transcatheter and surgical mitral valve repair (SMVr) in primary mitral regurgitation (MR) and MR with heart failure with reduced ejection fraction (HFrEF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this retrospective cohort study, we used the Nationwide Readmission Database to identify primary MR and MR with HFrEF patients who underwent transcatheter or SMVr from 2016 to 2019. A propensity score with 1:1 matching was applied. The primary outcome was a cumulative event rate of major adverse cardiovascular events (MACE), which was a composite of all-cause mortality, myocardial infarction, stroke, heart failure, cardiac arrest and mitral valve replacement. Other important secondary outcome was in-hospital mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After propensity score matching, 2187 matched pairs were found in the primary MR cohort and 2178 matched pairs were found in the MR-HFrEF cohort. Transcatheter mitral valve repair (TMVr) had significantly higher medium-term MACE compared with SMVr in both cohorts (primary MR: hazard ratio: 1.73, 95% confidence interval: 1.33\u20132.26, P \u2264 0.001; MR-HFrEF: hazard ratio: 2.00, 95% confidence interval: 1.58\u20132.54, P \u2264 0.001). TMVr showed similar in-hospital mortality in both cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Although TMVr showed better short-term outcomes, it had significantly higher medium-term MACE than SMVr in both cohorts. Thus, shared decision-making should be performed for TMVr after discussing the benefits and risks in patients who can undergo SMVr.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad391","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T03:21:05Z","timestamp":1700882465000},"source":"Crossref","is-referenced-by-count":6,"title":["Transcatheter versus surgical mitral valve repair in patients with mitral regurgitation"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-5878","authenticated-orcid":false,"given":"Monil","family":"Majmundar","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, University of Kansas Medical Center , Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2712-0670","authenticated-orcid":false,"given":"Kunal Nitinkumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, West Virginia University , Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Joseph\u2019s University Medical Centre , Paterson, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Akron General , Akron, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpkumar","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Harrington Heart and Vascular Institute, Case Western Reserve University , Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidakpal","family":"Panaich","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Iowa , Iowa, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0080-1660","authenticated-orcid":false,"given":"Ankur","family":"Kalra","sequence":"additional","affiliation":[{"name":"Franciscan Health , Lafayette, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"2024010504202731600_ezad391-B1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet (London, 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analysis of the 2014-2015 Nationwide readmissions databases","volume":"96","author":"Lima","year":"2020","journal-title":"Catheter Cardiovasc Interv"},{"key":"2024010504202731600_ezad391-B8","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/ccd.28479","article-title":"Impact of age and comorbidities on the effect of transcatheter versus surgical mitral valve repair on inpatient outcomes","volume":"95","author":"Jogu","year":"2020","journal-title":"Catheter Cardiovasc Interv"},{"key":"2024010504202731600_ezad391-B9","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.carrev.2020.05.021","article-title":"Temporal trends and outcomes of transcatheter mitral valve repair and surgical mitral valve intervention","volume":"21","author":"Elbadawi","year":"2020","journal-title":"Cardiovasc Revasc Med"},{"key":"2024010504202731600_ezad391-B10","doi-asserted-by":"crossref","first-page":"e2227746","DOI":"10.1001\/jamanetworkopen.2022.27746","article-title":"Comparison 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