{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:58:33Z","timestamp":1772607513354,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Thoracoscopic sympathicotomy may be an effective treatment for disabling facial blushing in selected patients. Short- and mid-term results are good but very long-term results are scarce in the medical literature and there is no knowledge which extent of sympathicotomy is better long-term for isolated facial blushing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We previously randomized 100 patients between a rib-oriented R2 or R2\u2013R3 sympathicotomy for isolated facial blushing, and reported local effects, side effects and quality of life after 12\u2009months. In the present study, we sent identical questionnaires to all patients after a median of 16\u2009years (interquartile range 15\u201317\u2009years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The response rate was 66%. Overall, 82% reported excellent or satisfactory results on facial blushing, with significant better local effect after R2 sympathicotomy compared with R2\u2013R3 sympathicotomy. Patients who underwent R2 sympathicotomy were also significantly more satisfied with the operation. We found no significant difference between R2 and R2\u2013R3 sympathicotomy in quality of life or rates of compensatory sweating (77%) and recurrence of blushing (41%) which was milder than preoperatively in most patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>R2 sympathicotomy should be the preferred approach for isolated facial blushing because of better local effect and higher satisfaction rates. Although this was a very long-term follow-up of the only randomized trial of its kind the response rate was limited leaving a risk of undetected bias.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezad414","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T22:47:49Z","timestamp":1702421269000},"source":"Crossref","is-referenced-by-count":3,"title":["Sympathicotomy for isolated facial blushing: long-term follow-up of a randomized trial"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-3073","authenticated-orcid":false,"given":"Finn Amundsen","family":"Dittberner","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , Odense, Denmark"},{"name":"Department of Cardiothoracic Surgery, Aarhus University Hospital , Skejby, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole Dan","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , Odense, Denmark"},{"name":"Department of Cardiothoracic Surgery, Aarhus University Hospital , Skejby, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Kristian","family":"Pilegaard","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , Odense, Denmark"},{"name":"Department of Cardiothoracic Surgery, Aarhus University Hospital , Skejby, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Ladegaard","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , Odense, Denmark"},{"name":"Department of Cardiothoracic Surgery, Aarhus University Hospital , Skejby, 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