{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:19:23Z","timestamp":1793398763583,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["RF_62040"],"award-info":[{"award-number":["RF_62040"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The use of del Nido cardioplegia has been increasing in popularity for adult cardiac surgery. However, the base solution, Plasma-Lyte A, is not always available in many countries. This prospective randomized controlled trial evaluated myocardial preservation and clinical outcomes when using lactated Ringer's solution (LRS) compared to Plasma-Lyte A as a base solution for del Nido cardioplegia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Adult patients undergoing first-time elective cardiac surgery for acquired heart disease, including isolated coronary artery bypass grafting, isolated valve surgery, combined valve surgery or concomitant coronary artery bypass grafting and valve surgery were randomized to receive either LRS (n\u2009=\u2009100) or Plasma-Lyte A (n\u2009=\u2009100).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>There were no significant differences between the 2 groups in terms of age, comorbidities, Society of Thoracic Surgeons risk score and type of procedures. The primary outcome, postoperative troponin-T at 24\u2009h, was similar in both groups (0.482 vs 0.524\u2009ng\/ml; P\u2009=\u20090.464). Other cardiac markers were also similar at all time points. The LRS group had a lower pH (7.228 vs 7.246; P\u2009=\u20090.005) and higher calcium levels (0.908 vs 0.358\u2009mmol\/l; P\u2009&amp;lt;\u20090.001) in the delivered cardioplegia, but there were no significant differences in clinical outcomes, such as ventricular fibrillation, left ventricular ejection fraction, inotrope\/vasopressor requirement, intra-aortic balloon pump support, intensive care unit stay, hospital stay, atrial fibrillation, red cell transfusion and complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The results suggest that LRS can be used as an alternative to Plasma-Lyte A as the base solution for del Nido cardioplegia, with similar myocardial preservation and clinical outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae018","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:25:53Z","timestamp":1705800353000},"source":"Crossref","is-referenced-by-count":10,"title":["Comparison of lactated Ringer's solution and Plasma-Lyte A as a base solution for del Nido cardioplegia: a prospective randomized trial"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-1384","authenticated-orcid":false,"given":"Narongrit","family":"Kantathut","sequence":"first","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimchanok","family":"Krathong","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siam","family":"Khajarern","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parinya","family":"Leelayana","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piya","family":"Cherntanomwong","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"2024030911291001800_ezae018-B1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1051\/ject\/201244098","article-title":"History and use of del Nido cardioplegia solution at Boston children's hospital","volume":"44","author":"Matte","year":"2012","journal-title":"J Extra Corpor Technol"},{"key":"2024030911291001800_ezae018-B2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jtcvs.2014.10.085","article-title":"del Nido versus Buckberg cardioplegia in adult isolated valve surgery","volume":"149","author":"Mick","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024030911291001800_ezae018-B3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1556984519863718","article-title":"A Systematic review and meta-analysis of del nido versus conventional cardioplegia in adult cardiac surgery","volume":"14","author":"An","year":"2019","journal-title":"Innovations (Phila)"},{"key":"2024030911291001800_ezae018-B4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.hlc.2020.10.016","article-title":"Myocardial protection in adult cardiac surgery with del Nido versus blood cardioplegia: a systematic review and meta-analysis","volume":"30","author":"Misra","year":"2021","journal-title":"Heart Lung Circ"},{"key":"2024030911291001800_ezae018-B5","first-page":"793","article-title":"Tepid modified Del Nido cardioplegia in adults undergoing cardiac surgery: a propensity-matched analysis","volume":"37","author":"Sevuk","year":"2022","journal-title":"Braz J Cardiovasc Surg"},{"key":"2024030911291001800_ezae018-B6","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1053\/j.jvca.2023.02.045","article-title":"Del Nido cardioplegia in adult cardiac surgery: meta-analysis of randomized clinical trials","volume":"37","author":"Fresilli","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"2024030911291001800_ezae018-B7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2459\/JCM.0000000000001506","article-title":"del Nido versus blood cardioplegia in adult cardiac surgery: a meta-analysis","volume":"24","author":"Malvindi","year":"2023","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"2024030911291001800_ezae018-B8","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.jtcvs.2017.09.146","article-title":"The use of del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial","volume":"155","author":"Ad","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024030911291001800_ezae018-B9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1051\/ject\/201951153","article-title":"Lactated ringer's as a base solution for del Nido cardioplegia","volume":"51","author":"Kantathut","year":"2019","journal-title":"J Extra Corpor Technol"},{"key":"2024030911291001800_ezae018-B10","first-page":"115","article-title":"Experience in the use of del Nido cardioplegia in Ramathibodi Hospital","volume":"100","author":"Kantathut","year":"2017","journal-title":"J Med Assoc Thai"},{"key":"2024030911291001800_ezae018-B11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/21501351211073610","article-title":"Plasmalyte-A based del Nido cardioplegia versus plain ringer based del Nido cardioplegia: double-blind randomized trial","volume":"13","author":"Talwar","year":"2022","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"2024030911291001800_ezae018-B12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/02184923211048332","article-title":"Modified del Nido versus blood cardioplegia in congenital cardiac surgery","volume":"30","author":"Sithiamnuai","year":"2022","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"2024030911291001800_ezae018-B13","doi-asserted-by":"crossref","DOI":"10.1002\/9781118900925","volume-title":"Perfusion for Congenital Heart Surgery: notes on Cardiopulmonary Bypass for a Complex Patient Population","author":"Matte","year":"2015"},{"key":"2024030911291001800_ezae018-B14","first-page":"I68","article-title":"Effect of the pH of cardioplegic solution on postarrest myocardial preservation","volume":"66","author":"Nugent","year":"1982","journal-title":"Circulation"},{"key":"2024030911291001800_ezae018-B15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-5223(19)38624-6","article-title":"Influence of the pH of cardioplegic solutions on intracellular pH, high-energy phosphates, and postarrest performance. Protective effects of acidotic, glutamate-containing cardioplegic perfusates","volume":"90","author":"Bernard","year":"1985","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezae018\/56286085\/ezae018.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/65\/3\/ezae018\/56913068\/ezae018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/65\/3\/ezae018\/56913068\/ezae018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T11:29:27Z","timestamp":1709983767000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/doi\/10.1093\/ejcts\/ezae018\/7582329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,20]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezae018","relation":{},"ISSN":["1873-734X"],"issn-type":[{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2024,1,20]]},"article-number":"ezae018"}}