{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:30Z","timestamp":1792785870036,"version":"4.5.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pommer-Jung Stiftung"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p\/>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The goal of this histological study was to assess the biocompatibility of vascular patches used in the repair of congenital heart defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We examined tissue-engineered bovine (n\u2009=\u20097) and equine (n\u2009=\u20097) patches and autologous human pericardium (n\u2009=\u20097), all explanted due to functional issues or follow-up procedures. Techniques like Movat-Verhoeff, von Kossa and immunohistochemical staining were used to analyse tissue composition, detect calcifications and identify immune cells. A semi-quantitative scoring system was implemented to evaluate the biocompatibility aspects, thrombus formation, extent of pannus, inflammation of pannus, cellular response to patch material, patch degradation, calcification and neoadventitial inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We observed distinct material degradation patterns among types of patches. Bovine patches showed collagen disintegration and exudate accumulation, whereas equine patches displayed edematous swelling and material dissolution. Biocompatibility scores were lower in terms of cellular response, degradation and overall score for human autologous pericardial patches compared to tissue-engineered types. The extent of pannus formation was not influenced by the type of patch. Bovine patches had notable calcifications causing tissue hardening, and foreign body giant cells were more frequently seen in equine patches. Plasma cells were frequently detected in the neointimal tissue of engineered patches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Our results confirm the superior biocompatibility of human autologous patches and highlight discernible variations in the changes of patch material and the cellular response to patch material between bovine and equine patches. Our approach implements the semi-quantitative scoring of various aspects of biocompatibility, facilitating a comparative quantitative analysis across all types of patches, despite their inherent differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae027","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T07:44:53Z","timestamp":1706255093000},"source":"Crossref","is-referenced-by-count":6,"title":["Tissue-engineered and autologous pericardium in congenital heart surgery: comparative histopathological study of human vascular explants"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7294-5140","authenticated-orcid":false,"given":"Katja","family":"Eildermann","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen , G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim","family":"Durashov","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen , G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Kuschnerus","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery\u2014Pediatric Heart Surgery, Deutsches Herzzentrum der Charit\u00e9 , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Poppe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen , G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Weixler","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery\u2014Pediatric Heart Surgery, Deutsches Herzzentrum der Charit\u00e9 , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Photiadis","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery\u2014Pediatric Heart Surgery, Deutsches Herzzentrum der Charit\u00e9 , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4110-7694","authenticated-orcid":false,"given":"Matthias","family":"Sigler","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Intensive Care Medicine, Georg-August University G\u00f6ttingen , G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6477-5727","authenticated-orcid":false,"given":"Peter","family":"Murin","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery\u2014Pediatric Heart Surgery, Deutsches Herzzentrum der Charit\u00e9 , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"2024031016495479100_ezae027-B1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.14503\/THIJ-14-4296","article-title":"Is autologous or heterologous pericardium better for valvuloplasty? 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