{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:58:42Z","timestamp":1791331122716,"version":"4.3.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21Y11913400"],"award-info":[{"award-number":["21Y11913400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The 9th edition of tumour\u2013node\u2013metastasis (TNM) staging for lung cancer was announced by Prof Hisao Asamura at the 2023 World Conference on Lung Cancer in Singapore. The purpose of this study was to externally validate and compare the latest staging of lung cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We collected 19\u00a0193 patients with stage IA\u2013IIIA non-small cell lung cancer (NSCLC) who underwent lobectomy from the Surveillance, Epidemiology and End Results database. Survival analysis by TNM stages was compared using the Kaplan\u2013Meier method and further analysed using univariable and multivariable Cox regression analyses. Receiver operating characteristic curves were used to assess model accuracy, Akaike information criterion, Bayesian information criterion and consistency index were used to compare the prognostic, predictive ability between the current 8th and 9th edition TNM classification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The 9th edition of the TNM staging system can better distinguish between IB and IIA patients on the survival curve (P\u2009&amp;lt;\u20090.0001). In both univariable and multivariable regression analysis, the 9th edition of the TNM staging system can differentiate any 2 adjacent staging patients more evenly than the 8th edition. The 9th and the 8th edition TNM staging have similar predictive power and accuracy for the overall survival of patients with NSCLC [TNM 9th vs 8th, area under the curve: 62.4 vs 62.3; Akaike information criterion: 166\u00a0182.1 vs 166\u00a0131.6; Bayesian information criterion: 166\u00a0324.3 vs 166\u00a0273.8 and consistency index: 0.650 (0.003) vs 0.651(0.003)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our external validation demonstrates that the 9th edition of TNM staging for NSCLC is reasonable and valid. The 9th edition of TNM staging for NSCLC has near-identical prognostic accuracy to the 8th edition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae071","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T10:05:36Z","timestamp":1709287536000},"source":"Crossref","is-referenced-by-count":14,"title":["Validation of the 9th edition of the TNM staging system for non-small cell lung cancer with lobectomy in stage IA\u2013IIIA"],"prefix":"10.1093","volume":"65","author":[{"given":"Rang-Rang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University , Shanghai, P. R. China"},{"name":"Department of Thoracic Surgery, Huadong Hospital Affiliated to Fudan University , Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University , Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Medicine, Tongji University , Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ye","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, Tongji University , Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University , Shanghai, P. R. China"},{"name":"Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences , Hangzhou, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-1801","authenticated-orcid":false,"given":"Dong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University , Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"2024033016154653700_ezae071-B1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2024033016154653700_ezae071-B2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(21)00312-3","article-title":"Lung cancer","volume":"398","author":"Thai","year":"2021","journal-title":"Lancet"},{"key":"2024033016154653700_ezae071-B3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41571-021-00501-4","article-title":"Evolution of systemic therapy for stages I-III non-metastatic non-small-cell lung cancer","volume":"18","author":"Chaft","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"2024033016154653700_ezae071-B4","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37\u2008513\u2008025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"},{"key":"2024033016154653700_ezae071-B5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0140-6736(16)30958-8","article-title":"Lung cancer: current therapies and new targeted treatments","volume":"389","author":"Hirsch","year":"2017","journal-title":"Lancet"},{"key":"2024033016154653700_ezae071-B6","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0003-4975(95)00537-U","article-title":"Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group","volume":"60","author":"Ginsberg","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"2024033016154653700_ezae071-B7","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/S0140-6736(10)62101-0","article-title":"Non-small-cell lung cancer","volume":"378","author":"Goldstraw","year":"2011","journal-title":"Lancet"},{"key":"2024033016154653700_ezae071-B8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC Lung Cancer Staging Project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J Thorac Oncol"},{"key":"2024033016154653700_ezae071-B9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.6004\/jnccn.2022.7021","article-title":"Perioperative systemic therapy for resectable non-small cell lung cancer","volume":"20","author":"Muthusamy","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"2024033016154653700_ezae071-B10","doi-asserted-by":"crossref","first-page":"n2363","DOI":"10.1136\/bmj.n2363","article-title":"Advances in systemic therapy for non-small cell lung cancer","volume":"375","author":"Miller","year":"2021","journal-title":"BMJ"},{"key":"2024033016154653700_ezae071-B11","author":"Asamura"},{"key":"2024033016154653700_ezae071-B12","author":"Gebhart"},{"key":"2024033016154653700_ezae071-B13","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jtho.2022.02.008","article-title":"The International Association for the Study of Lung Cancer Staging Project: methods and guiding principles for the development of the ninth edition TNM classification","volume":"17","author":"Detterbeck","year":"2022","journal-title":"J Thorac Oncol"},{"key":"2024033016154653700_ezae071-B14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chest.2016.10.010","article-title":"The eighth edition lung cancer stage classification","volume":"151","author":"Detterbeck","year":"2017","journal-title":"Chest"},{"key":"2024033016154653700_ezae071-B15","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/JTO.0b013e31812f3c1a","article-title":"The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours","volume":"2","author":"Goldstraw","year":"2007","journal-title":"J Thorac Oncol"},{"key":"2024033016154653700_ezae071-B16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jtho.2023.01.088","article-title":"IASLC Lung Cancer Staging Project: the new database to inform revisions in the ninth edition of the TNM classification of lung cancer","volume":"18","author":"Asamura","year":"2023","journal-title":"J Thorac Oncol"},{"key":"2024033016154653700_ezae071-B17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.lungcan.2022.03.011","article-title":"External validation of the eighth edition of the TNM classification for lung cancer in small cell lung cancer","volume":"170","author":"Tan","year":"2022","journal-title":"Lung Cancer"},{"key":"2024033016154653700_ezae071-B18","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1016\/j.cllc.2017.04.001","article-title":"Validation of the eighth edition of the TNM staging system for lung cancer in 2043 surgically treated patients with non-small-cell lung cancer","volume":"18","author":"Chen","year":"2017","journal-title":"Clin Lung Cancer"},{"key":"2024033016154653700_ezae071-B19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jjco\/hyy142","article-title":"New revisions and current issues in the eighth edition of the TNM classification for non-small cell lung cancer","volume":"49","author":"Hattori","year":"2019","journal-title":"Jpn J Clin Oncol"},{"key":"2024033016154653700_ezae071-B20","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/ejcts\/ezz147","article-title":"Comparison between lymph node station- and zone-based classification for the future revision of node descriptors proposed by the International Association for the Study of Lung Cancer in surgically resected patients with non-small-cell lung cancer","volume":"56","author":"Yun","year":"2019","journal-title":"Eur J Cardiothorac Surg"},{"key":"2024033016154653700_ezae071-B21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/annonc\/mdv560","article-title":"Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer","volume":"27","author":"Donnem","year":"2016","journal-title":"Ann Oncol"},{"key":"2024033016154653700_ezae071-B22","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jtho.2022.02.005","article-title":"Clinicopathologic and genotypic features of lung adenocarcinoma characterized by the International Association for the Study of Lung Cancer Grading System","volume":"17","author":"Fujikawa","year":"2022","journal-title":"J Thorac Oncol"},{"key":"2024033016154653700_ezae071-B23","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/cncr.32699","article-title":"Blood-based circulating tumor DNA mutations as a diagnostic and prognostic biomarker for lung cancer","volume":"126","author":"Leung","year":"2020","journal-title":"Cancer"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezae071\/56810491\/ezae071.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/65\/3\/ezae071\/57127977\/ezae071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/65\/3\/ezae071\/57127977\/ezae071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T16:16:04Z","timestamp":1711815364000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/doi\/10.1093\/ejcts\/ezae071\/7616984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,29]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezae071","relation":{},"ISSN":["1873-734X"],"issn-type":[{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2024,2,29]]},"article-number":"ezae071"}}