{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:48:53Z","timestamp":1764996533181,"version":"3.41.2"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p\/><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Solitary fibrous tumours of the pleura (SFTP) are historically considered to be benign soft tissue neoplasms. However, a clinical relevant number of these neoplasms have malignant histological features. The objective of this study was to evaluate the percentage of SFTP presenting unfavourable clinical behaviour in order to predict negative long-term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective review of 74 patients treated at 4 hospitals between 1990 and 2013 was performed. The median follow-up was 10\u2009years (range: 1\u201320\u2009years). Risk of tumour recurrence and metastases (unfavourable clinical behaviour) with regard to histology using the Kaplan\u2013Meier and Cox proportional hazards methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mean age was 61\u2009years (SD 12.75\u2009years). There were 31 male patients (58%) and 43 female patients (42%). Tumour size ranged from 1 to 30\u2009cm (mean 9.09\u2009cm; SD 6.22\u2009cm). Complete resection (R0) was achieved by minimally invasive thoracoscopic resection in 29% and thoracotomy in 57%; 25% of SFTPs showed histological evidence of malignancy, according to England criteria. Recurrence occurred in 21% and 10% of patients had metastases; 83% of patients with metastases and 39% of patients with recurrence died within 5 years. The median recurrence-free survival for histologically benign SFTP was not reached, compared to 8\u2009years for malignant SFTP. The five-year overall survival rate was 84%. Mitotic rate \u22651\/10 HPF, high cellularity, nuclear atypia, Ki-67 level &amp;gt;5% and poorly circumscribed (sessile) growth pattern were associated with poor long-term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Pathological differentiation of SFTP morphology into pedunculated, well circumscribed and poorly circumscribed (sessile) growth pattern is recommended. Due to the misleading classification into histologically benign and malignant, all unpedunculated SFTP should be classified as potentially aggressive. Lifelong follow-up is mandatory.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejcts\/ezae096","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T01:12:27Z","timestamp":1710378747000},"source":"Crossref","is-referenced-by-count":3,"title":["Solitary fibrous tumours of the pleura: do we need a different perspective on malignancy?"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-6607","authenticated-orcid":false,"given":"Niels Michael","family":"D\u00f6rr","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Martha\u2013Maria Hospital Halle\u2014D\u00f6lau , Halle, Germany"},{"name":"Medical Faculty of the Martin Luther University Halle-Wittenberg, University Hospital Halle , Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Martha\u2013Maria Hospital Halle\u2014D\u00f6lau , Halle, Germany"},{"name":"Medical Faculty of the Martin Luther University Halle-Wittenberg, University Hospital Halle , Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Martha\u2013Maria Hospital Halle\u2014D\u00f6lau , Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Zinne","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Toennies","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, HELIOS Hospital Emil von Behring , Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Schega","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Johanniter Hospital Treuenbrietzen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Ritter","sequence":"additional","affiliation":[{"name":"Department of Radiology, Helios Hospital Hildesheim , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Decker","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Heinrich-Braun Hospital Zwickau , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"H\u00f6lsken","sequence":"additional","affiliation":[{"name":"Department of Pathology, Martha\u2013Maria Hospital Halle\u2014D\u00f6lau , Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Sch\u00fctte","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Martha\u2013Maria Hospital Halle\u2014D\u00f6lau , Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Biancosino","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, HELIOS University Hospital Wuppertal , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"2024033003061985800_ezae096-B1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.clon.2009.03.006","article-title":"Diagnosis and staging of lung and pleural malignancy\u2014an overview of tissue sampling techniques and the implications for pathological assessment","volume":"21","author":"Andrews","year":"2009","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"2024033003061985800_ezae096-B2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ccm.2012.12.001","article-title":"Rare pleural tumors","volume":"34","author":"Erb","year":"2013","journal-title":"Clin Chest Med"},{"key":"2024033003061985800_ezae096-B3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/00000478-198908000-00003","article-title":"Localized benign and malignant fibrous tumors of the pleura. 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