{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:54Z","timestamp":1753876254565,"version":"3.41.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Institute of Respiratory Medicine","award":["Ggyfz 202321"],"award-info":[{"award-number":["Ggyfz 202321"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To evaluate the safety and feasibility of removing drainage tubes at larger size of air leak in patients with prolonged air leak after pulmonary surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Ninety-five patients who underwent pulmonary surgery with prolonged air leak in our centre were enrolled in this randomized controlled, single-centre, non-inferiority study. The drainage tube was clamped with a stable size of air leak observed over the last 6\u2009h, which was quantified by gas flow rate using the digital drainage system. The control group (n\u2009=\u200948) and the study group (n\u2009=\u200946) had their drainage tube clamped at 0\u201320 ml\/min and 60\u201380 ml\/min, respectively. We continuously monitored clinical symptoms, conducted imaging and laboratory examinations, and decided whether to reopen the drainage tube.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The reopening rate in the study group was not lower than that in the control group (2.08% vs 6.52%, P\u2009&amp;gt;\u20090.05). The absolute difference in reopening rate was 4.44% (95% confidence interval \u20130.038 to 0.126), with an upper limit of 12.6% below the non-inferiority margin (15%). There were significant differences in the length of stay [16.5 (13\u201324.75) vs 13.5 (12\u201319.25), P\u2009=\u20090.017] and the duration of drainage [12 (9.25\u201318.50) vs 10 (8\u201312.25), P\u2009=\u20090.007] between the control and study groups. No notable differences were observed in chest X-ray results 14\u2009days after discharge or in the readmission rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>For patients with prolonged air leak, removing drainage tubes at larger size of air leak demonstrated similar safety compared to smaller size of air leak, and can shorten both length of stay and drainage duration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>Name of registry: Gas flow threshold for safe removal of chest drainage in patients with alveolar-pleural fistula prolonged air leak after pulmonary surgery. Registration number: ChiCTR2200067120. URL: https:\/\/www.chictr.org.cn\/<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae097","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T01:12:31Z","timestamp":1710378751000},"source":"Crossref","is-referenced-by-count":2,"title":["Chest tube removal at different gas flows in prolonged air leak: a randomized non-inferiority trial"],"prefix":"10.1093","volume":"65","author":[{"given":"Xinyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University , Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University , Beijing, 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