{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:17:38Z","timestamp":1791393458388,"version":"4.3.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202301ZYTS456"],"award-info":[{"award-number":["YDZJ202301ZYTS456"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20231207KJ"],"award-info":[{"award-number":["JJKH20231207KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Development Fund of the First Hospital of Jilin University","award":["04046910001"],"award-info":[{"award-number":["04046910001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Tracheal reconstruction post-extensive resection remains an unresolved challenge in thoracic surgery. This study evaluates the use of aortic allografts (AAs) for tracheal replacement and reconstruction in a rat model, aiming to elucidate the underlying mechanisms of tracheal regeneration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>AAs from female rats were employed for tracheal reconstruction in 36 male rats, with the replacement exceeding half of the tracheal length. To avert collapse, silicone stents were inserted into the AA lumens. No immunosuppressive therapy was administered. The rats were euthanized biweekly, and the AAs were examined for neovascularization, cartilage formation, respiratory epithelial ingrowth, submucosal gland regeneration and the presence of the Sex-determining region of Y-chromosome (SRY) gene.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>All procedures were successfully completed without severe complications. The AA segments were effectively integrated into the tracheal framework, with seamless distinction at suture lines. Histological analysis indicated an initial inflammatory response, followed by the development of squamous and mucociliary epithelia, new cartilage ring formation and gland regeneration. In situ hybridization identified the presence of the SRY gene in newly formed cartilage rings, confirming that regeneration was driven by recipient cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This study demonstrates the feasibility of AAs transforming into functional tracheal conduits, replicating the main structural and functional characteristics of the native trachea. The findings indicate that this approach offers a novel pathway for tissue regeneration and holds potential for treating extensive tracheal injuries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae115","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T19:55:36Z","timestamp":1711482936000},"source":"Crossref","is-referenced-by-count":12,"title":["Feasibility of tracheal reconstruction using silicone-stented aortic allografts"],"prefix":"10.1093","volume":"65","author":[{"given":"Shixiong","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University , Changchun, China"},{"name":"Department of Thoracic Surgery, The First Hospital of Jilin University , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University , Changchun, China"},{"name":"Department of Thoracic Surgery, The First Hospital of Jilin University , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feixiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexing","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyue","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University , Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"2024040600113033800_ezae115-B1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0003-4975(02)04108-5","article-title":"Development of tracheal surgery: a historical review. Part 1: techniques of tracheal surgery","volume":"75","author":"Grillo","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2024040600113033800_ezae115-B2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1001\/jama.2018.4653","article-title":"Feasibility of bioengineered tracheal and bronchial reconstruction using stented aortic matrices","volume":"319","author":"Martinod","year":"2018","journal-title":"JAMA"},{"key":"2024040600113033800_ezae115-B3","doi-asserted-by":"crossref","first-page":"210154","DOI":"10.1183\/16000617.0154-2021","article-title":"Development and clinical translation of tubular constructs for tracheal tissue engineering: a review","volume":"30","author":"Soriano","year":"2021","journal-title":"Eur Respir Rev"},{"key":"2024040600113033800_ezae115-B4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.asjsur.2017.02.007","article-title":"Transplantation of the decellularized tracheal allograft in animal model (rabbit)","volume":"41","author":"Ershadi","year":"2018","journal-title":"Asian J Surg"},{"key":"2024040600113033800_ezae115-B5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/TP.0b013e31822a4082","article-title":"Bone marrow-derived mesenchymal stem cells enhance cryopreserved trachea allograft epithelium regeneration and vascular endothelial growth factor expression","volume":"92","author":"Han","year":"2011","journal-title":"Transplantation"},{"key":"2024040600113033800_ezae115-B6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.reth.2023.09.004","article-title":"Tracheal replacement with aortic grafts: bench to clinical practice","volume":"24","author":"Wei","year":"2023","journal-title":"Regen Ther"},{"key":"2024040600113033800_ezae115-B7","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.21037\/jtd.2018.07.108","article-title":"Aortic allografts: final destination?\u2014a summary of clinical tracheal substitutes","volume":"10","author":"Siddiqi","year":"2018","journal-title":"J Thorac Dis"},{"key":"2024040600113033800_ezae115-B8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.xjtc.2023.05.021","article-title":"Preliminary results in tracheal replacement using stented aortic matrices for primary extensive tracheal cancer","volume":"21","author":"Onorati","year":"2023","journal-title":"JTCVS Tech"},{"key":"2024040600113033800_ezae115-B9","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1111\/ajt.17137","article-title":"Airway replacement using stented aortic matrices: long-term follow-up and results of the TRITON-01 study in 35 adult patients","volume":"22","author":"Martinod","year":"2022","journal-title":"Am J Transplant"},{"key":"2024040600113033800_ezae115-B10","doi-asserted-by":"crossref","first-page":"1702211","DOI":"10.1183\/13993003.02211-2017","article-title":"Tracheal replacement","volume":"51","author":"Etienne","year":"2018","journal-title":"Eur Respir J"},{"key":"2024040600113033800_ezae115-B11","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1001\/jama.2018.4652","article-title":"Has reconstruction of the central airways been transformed?: from aorta to trachea","volume":"319","author":"Rusch","year":"2018","journal-title":"JAMA"},{"key":"2024040600113033800_ezae115-B12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41536-023-00312-4","article-title":"Regeneration of tracheal neotissue in partially decellularized scaffolds","volume":"8","author":"Tan","year":"2023","journal-title":"NPJ Regen Med"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezae115\/57094094\/ezae115.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/65\/4\/ezae115\/57173908\/ezae115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/article-pdf\/65\/4\/ezae115\/57173908\/ezae115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:57:50Z","timestamp":1712365070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/doi\/10.1093\/ejcts\/ezae115\/7635161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,3,29]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezae115","relation":{},"ISSN":["1873-734X"],"issn-type":[{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4,1]]},"published":{"date-parts":[[2024,3,26]]},"article-number":"ezae115"}}