{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:51:33Z","timestamp":1753876293835,"version":"3.41.2"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009954","name":"Taiho Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009954","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Comprehensive Support Project for Oncology Research"},{"name":"Public Health Research Foundation in Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>To validate or refute the hypothesis that non-small-cell lung cancers (NSCLC) with ground-glass areas (GGA+) within the tumour on high-resolution computed tomography are associated with a more favourable prognosis than those without GGA (GGA\u2212).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We analysed data from a multicentre observational cohort study in Japan including 5005 patients with completely resected pathological stage I NSCLC, who were excluded from the Japan Clinical Oncology Group (JCOG) 0707 trial on oral adjuvant treatment during the enrolment period. The patients\u2019 medical and pathological records were assessed retrospectively by physicians and re-staged according to the 8th tumour, node, metastasis edition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of the 5005 patients, 2388 (48%) were ineligible for the JCOG0707 trial and 2617 (52%) were eligible but were not enrolled. A total of 958 patients (19.1%) died. Patients with GGA+ NSCLC and pathological invasion \u22643\u2009cm showed significantly better overall survival than others. In patients with tumours with an invasive portion \u22644\u2009cm, GGA+ was associated with better survival. The prognoses of patients with GGA+ T2a and GGA\u2212 T1c tumours were similar (5-year overall survival: 84.6% vs 83.1%, respectively). The survival with T2b or more tumours appeared unaffected by GGA, and GGA was not prognostic in these larger tumours.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Patients with GGA+ NSCLC on high-resolution computed tomography and \u22644\u2009cm invasion size may have a better prognosis than patients with solid GGA\u2212 tumours of the same T-stage. However, the presence or absence of radiological GGA has little impact on the prognosis of patients with NSCLC with greater (&amp;gt;4\u2009cm) pathological invasion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae158","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T22:32:32Z","timestamp":1712701952000},"source":"Crossref","is-referenced-by-count":1,"title":["Prognostic significance of ground-glass areas within tumours in non-small-cell lung cancer"],"prefix":"10.1093","volume":"65","author":[{"given":"Hiroyuki","family":"Sakurai","sequence":"first","affiliation":[{"name":"Division of Respiratory Surgery, Nihon University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-5054","authenticated-orcid":false,"given":"Yasushi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, National Cancer Center Hospital , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Yoh","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, National Cancer Center Hospital East , Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-6364","authenticated-orcid":false,"given":"Kazuya","family":"Takamochi","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Graduate School of Medicine, Juntendo University , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Shukuya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-8563","authenticated-orcid":false,"given":"Tomoyuki","family":"Hishida","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Keio University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, National Cancer Center Hospital East , Kashiwa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tokyo Medical University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-2628","authenticated-orcid":false,"given":"Yasuhisa","family":"Ohde","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Shizuoka Cancer Center , Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakae","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, The Cancer Institute Hospital of JFCR , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Taguri","sequence":"additional","affiliation":[{"name":"Department of Data Science, Tokyo Medical University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Kunitoh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Japanese Red Cross Medical Center , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"2024051411373801400_ezae158-B1","first-page":"105","volume-title":"TNM Classification of Malignant Tumours","author":"Brierley","year":"2017","edition":"8th edn"},{"key":"2024051411373801400_ezae158-B2","volume-title":"TNM supplement. 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