{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:14:31Z","timestamp":1793146471480,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JOTEC GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The aim of this multicentre study was to demonstrate the safety and clinical performance of E-vita OPEN NEO Stent Graft System (Artivion, Inc.) in the treatment of aneurysm or dissection, both acute and chronic, in the ascending aorta, aortic arch and descending thoracic aorta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this observational study of 12 centres performed in Europe and in Asia patients were enrolled between December 2020 and March 2022. All patients underwent frozen elephant trunk using E-vita OPEN NEO Stent Graft System. Primary end point was the rate of all-cause mortality at 30\u2009days and secondary end points included further clinical and safety data are reported up to 3\u20136\u2009months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 100 patients (66.7% male; mean age, 57.7\u2009years) were enrolled at 12 sites. A total of 99 patients underwent surgery using the E-vita OPEN NEO for acute or subacute type A aortic dissection (n\u2009=\u200937), chronic type A aortic dissection (n\u2009=\u200933) or thoracic aortic aneurysm (n\u2009=\u200929), while 1 patient did not undergo surgery. Device technical success at 24\u2009h was achieved in 97.0%. At discharge, new disabling stroke occurred in 4.4%, while new paraplegia and new paraparesis was reported in 2.2% and 2.2%, respectively. Renal failure requiring permanent (&amp;gt;90\u2009days) dialysis or hemofiltration at discharge was observed in 3.3% of patients. Between discharge and the 3\u20136\u2009months visit, no patients experienced new disabling stroke, new paraplegia or new paraparesis. The 30-day mortality was 5.1% and the estimated 6-month survival rate was 91.6% (standard deviation: 2.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Total arch replacement with the E-vita OPEN NEO can be performed with excellent results in both the acute and chronic setting. This indicates that E-vita OPEN NEO can be used safely, including in the setting of acute type A aortic dissection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae206","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T20:15:53Z","timestamp":1717186553000},"source":"Crossref","is-referenced-by-count":12,"title":["E-vita OPEN NEO in the treatment of acute or chronic aortic pathologies: first interim results of the NEOS study"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8984-6779","authenticated-orcid":false,"given":"Konstantinos","family":"Tsagakis","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, West-German Heart and Vascular Center, University Hospital Essen , Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin, Germany"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zierer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine, Johannes Kepler University Linz , Linz, Austria"},{"name":"Department of Cardiovascular and Thoracic Surgery, Wels-Grieskirchen Clinic , Wels, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-2645","authenticated-orcid":false,"given":"Andreas","family":"Martens","sequence":"additional","affiliation":[{"name":"Clinic of Cardiac Surgery, University Hospital Oldenburg, Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel-Sebastian","family":"Dohle","sequence":"additional","affiliation":[{"name":"Department of Heart and Vascular Surgery, University Medical Center of the Johannes Gutenberg-University Mainz , Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University , Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph Hung-Leung","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Cardiothoracic Surgery, the Chinese University Hong Kong , Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazimierz","family":"Widenka","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, District Hospital No. 2, University of Rzesz\u00f3w , Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Liakopoulos","sequence":"additional","affiliation":[{"name":"Departemnt of Cardiac Surgery, Kerckhoff-Clinic, Campus Kerckhoff, University of Gie\u00dfen , Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Borger","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Heart Center Leipzig , Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aung Ye","family":"Oo","sequence":"additional","affiliation":[{"name":"St Bartholomew\u2019s Hospital, Barts Health NHS Trust , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Holubec","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Frankfurt, Goethe University , Frankfurt, 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