{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:40:32Z","timestamp":1787859632869,"version":"build-2784847793"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Limited data are available from randomized trials comparing outcomes between transcatheter aortic valve replacement (TAVR) and surgery in patients with different risks and with follow-up of at least 4\u2009years or longer. In this large, population-based cohort study, long-term mortality and morbidity were investigated in patients undergoing aortic valve replacement (AVR) for severe aortic stenosis using a surgically implanted bioprosthesis (surgical\/biological aortic valve replacement; sB-AVR) or TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Individual data from the Austrian Insurance Funds from 2010 through 2020 were analysed. The primary outcome was all-cause mortality, assessed in the overall and propensity score-matched populations. Secondary outcomes included reoperation and cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>From January 2010 through December 2020, a total of 18\u00a0882 patients underwent sB-AVR (n\u2009=\u200911\u00a0749; 62.2%) or TAVR (n\u2009=\u20097133; 37.8%); median follow-up was 5.8 (95% CI 5.7\u20135.9) years (maximum 12.3\u2009years). The risk of all-cause mortality was higher with TAVR compared with sB-AVR: hazard ratio 1.552, 95% confidence interval (CI) 1.469\u20131.640, P\u2009&amp;lt;\u20090.001; propensity score-matched hazard ratio 1.510, 1.403\u20131.625, P\u2009&amp;lt;\u20090.001. Estimated median survival was 8.8\u2009years (95% CI 8.6\u20139.1) with sB-AVR versus 5\u2009years (4.9\u20135.2) with TAVR. Estimated 5-year survival probability was 0.664 (0.664\u20130.686) with sB-AVR versus 0.409 (0.378\u20130.444) with TAVR overall, and 0.690 (0.674\u20130.707) and 0.560 (0.540\u20130.582), respectively, with propensity score matching. Separate subgroup analyses for patients aged 65\u201375\u2009years and &amp;gt;75\u2009years indicated a significant survival benefit in patients selected for sB-AVR in both groups. Other predictors of mortality were age, sex, previous heart failure, diabetes and chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In this retrospective national population-based study, selection for TAVR was significantly associated with higher all-cause mortality compared with sB-AVR in patients \u226565\u2009years with severe, symptomatic aortic stenosis in the &amp;gt;2-year follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae214","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T17:56:44Z","timestamp":1718128604000},"source":"Crossref","is-referenced-by-count":28,"title":["Selection for transcatheter versus surgical aortic valve replacement and mid-term survival: results of the AUTHEARTVISIT study"],"prefix":"10.1093","volume":"66","author":[{"given":"Johann","family":"Auer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I with Cardiology and Intensive Care, St Josef Hospital Braunau , Braunau am Inn, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavla","family":"Krotka","sequence":"additional","affiliation":[{"name":"Center for Medical Data Science, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Reichardt","sequence":"additional","affiliation":[{"name":"Austrian Social Health Insurance Fund , Eisenstadt, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-1525","authenticated-orcid":false,"given":"Denise","family":"Traxler","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Surgery, Medical University of Vienna , Vienna, Austria"},{"name":"Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology , Vienna, Austria"},{"name":"Department of Oral and Maxillofacial Surgery, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Wendt","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital St Georg Leipzig , Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mildner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik Jan","family":"Ankersmit","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Surgery, Medical University of Vienna , Vienna, Austria"},{"name":"Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Graf","sequence":"additional","affiliation":[{"name":"Center for Medical Data Science, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"2024082009553895800_ezae214-B1","doi-asserted-by":"crossref","first-page":"e13736","DOI":"10.1111\/eci.13736","article-title":"Mechanical aortic valve prostheses offer a survival benefit in 50-65 year olds: AUTHEARTVISIT study","volume":"52","author":"Traxler","year":"2022","journal-title":"Eur J Clin Invest"},{"key":"2024082009553895800_ezae214-B2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart 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