{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:57:34Z","timestamp":1787162254527,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>To date, there are no standardized treatment algorithms or recommendations for patients with infective endocarditis (IE) and concomitant spondylodiscitis (SD). Therefore, our aim was to analyse whether the sequence of surgical treatment of IE and SD has an impact on postoperative outcome and to identify risk factors for survival and postoperative recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients with IE underwent surgery in 4 German university hospitals between 1994 and 2022. Univariable and multivariable analyses were performed to identify possible predictors of 30-day\/1-year mortality and recurrence of IE and\/or SD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>From the total IE cohort (n\u2009=\u20093991), 150 patients (4.4%) had concomitant SD. Primary surgery for IE was performed in 76.6%, and primary surgery for SD in 23.3%. The median age was 70.0 (64.0\u201375.6) years and patients were mostly male (79.5%). The most common pathogens detected were enterococci and Staphylococcus aureus followed by streptococci, and coagulase-negative Staphylococci. If SD was operated on first, 30-day mortality was significantly higher than if IE was operated on 1st (25.7% vs 11.4%; P\u2009=\u20090.037) and we observed a tendency for a higher 1-year mortality. If IE was treated 1st, we observed a higher recurrence rate within 1 year (12.2% vs 0%; P\u2009=\u20090.023). Multivariable analysis showed that primary surgery for SD was an independent predictor of 30-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Primary surgical treatment for SD was an independent risk factor for 30-day mortality. When IE was treated surgically 1st, the recurrence rate of IE and\/or SD was higher.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae246","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T18:55:07Z","timestamp":1720119307000},"source":"Crossref","is-referenced-by-count":6,"title":["Infective endocarditis and spondylodiscitis\u2014impact of sequence of surgical therapy on survival and recurrence rate"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-5549","authenticated-orcid":false,"given":"Carolyn","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, University of Cologne , Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Misfeld","sequence":"additional","affiliation":[{"name":"University Department of Cardiac Surgery, Leipzig Heart Center , Leipzig, Germany"},{"name":"Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital , Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Friedrich Schiller University Jena , Jena, Germany"},{"name":"Department of Cardiac Surgery, HKZ Klinikum Herfeld-Rotenburg Rotenburg a.d. 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