{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:58:18Z","timestamp":1781578698527,"version":"3.54.5"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100001491","name":"Belgian American Educational Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The potential risk of autograft dilatation and homograft stenosis after the Ross procedure mandates lifelong follow-up. This retrospective cohort study aimed to determine long-term outcome of the Ross procedure, investigating autograft and homograft failure patterns leading to reintervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>All adults who underwent the Ross procedure between 1991 and 2018 at the University Hospitals Leuven were included, with follow-up data collected retrospectively. Autograft implantation was performed using the full root replacement technique. The primary end-point was long-term survival. Secondary end-points were survival free from any reintervention, autograft or homograft reintervention-free survival, and evolution of autograft diameter, homograft gradient and aortic regurgitation grade over time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 173 adult patients (66% male) with a median age of 32\u2009years (range 18\u201358\u2009years) were included. External support at both the annulus and sinotubular junction was used in 38.7% (67\/173). Median follow-up duration was 11.1\u2009years (IQR, 6.4\u201315.9; 2065 patient-years) with 95% follow-up completeness. There was one (0.6%) perioperative death. Kaplan\u2013Meier estimate for 15-year survival was 91.1% and Ross-related reintervention-free survival was 75.7% (autograft: 83.5%, homograft: 85%). Regression analyses demonstrated progressive neoaortic root dilatation (0.56\u2009mm\/year) and increase in homograft gradient (0.72\u2009mmHg\/year).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The Ross procedure has the potential to offer excellent long-term survival and reintervention-free survival. These long-term data further confirm that the Ross procedure is a suitable option in young adults with aortic valve disease which should be considered on an individual basis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae267","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T01:39:41Z","timestamp":1720748381000},"source":"Crossref","is-referenced-by-count":4,"title":["Long-term outcome after the Ross procedure in 173 adults with up to 25 years of follow-up"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-4568","authenticated-orcid":false,"given":"Lucas","family":"Van Hoof","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, UZ Leuven , Herestraat 49 , 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Rooyackers","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, UZ Leuven , Herestraat 49 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