{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:59:33Z","timestamp":1779206373013,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The use of ventricular assist devices in children is increasing. However, absolute numbers in individual centers and countries remain small. Collaborative efforts such as the Paedi-EUROMACS are therefore essential in order to combine international experience with paediatric ventricular assist devices. In this paper, the results from the fourth Paedi-EUROMACS report are presented.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>All paediatric (&amp;lt;19\u2009years) patients supported by a ventricular assist device from the EUROMACS database were included. Patients are stratified into a congenital heart disease group and a group with a non-congenital aetiology. Endpoints included mortality, transplantation and recovery. Cox proportional hazard models were used to explore associated factors for mortality, cerebrovascular accident, and pump thrombosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>590 primary implantations were included. The congenital group was significantly younger (2.5 versus 8.0\u2009years respectively, p\u2009&amp;lt;\u20090.001) and were more commonly supported by a pulsatile flow device (73.5% vs 59.9%, p\u2009&amp;lt;\u20090.001). Mortality was significantly higher in the congenital group (30.8 vs 20.4%; p\u2009=\u20090.009) than in the non-congenital group. However, in multivariable analyses, congenital heart disease was not significantly associated with mortality (HR 1.285, CI 0.8111\u20132.036, p\u2009=\u20090.740). Pump thrombosis was the most frequently reported adverse event (377 events in 132 patients; 0.925 events per patient-year) and was significantly associated with BSA (HR 0.524\u2009CI 0.333\u20130.823, p\u2009=\u20090.005), congenital heart disease (HR 1.641\u2009CI 1.054\u20132.555, p\u2009=\u20090.028) and pulsatile flow support (HR 2.345\u2009CI 1.406\u20133.910, p\u2009=\u20090.001) in multivariable analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This fourth Paedi-EUROMACS report highlights the increasing use of paediatric ventricular assist devices. The patient populations with congenital and non-congenital aetiology exhibit distinct characteristics and clinical outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae276","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T02:17:48Z","timestamp":1721441868000},"source":"Crossref","is-referenced-by-count":6,"title":["The european registry for patients with mechanical circulatory support (EUROMACS): fourth paediatric EUROMACS (Paedi-EUROMACS) report"],"prefix":"10.1093","author":[{"given":"Sofie","family":"Rohde","sequence":"first","affiliation":[{"name":"Erasmus University Medical Center Department of Cardio-thoracic surgery, , Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joeri","family":"van Puyvelde","sequence":"additional","affiliation":[{"name":"Katholieke Universiteit Leuven , Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M","family":"Veen","sequence":"additional","affiliation":[{"name":"Erasmus University Medical Center Department of Cardio-thoracic surgery, , Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schweiger","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Z\u00fcrich Department of Congenital Pediatric Surgery, , Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Biermann","sequence":"additional","affiliation":[{"name":"Children's Heart Clinic, University Heart & Vascular Center Hamburg Department of Congenital and Pediatric Heart Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Amodeo","sequence":"additional","affiliation":[{"name":"Catholic University of Sacred Heart, Rome, Italy- Bambino Ges\u00f9 Children's Hospital, IRCCS Department of Cardiovascular and Pneumological Sciences, , Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Martens","sequence":"additional","affiliation":[{"name":"Universitair Ziekenhuis Gent , Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Damman","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen , Groningen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Gollmann-Tepek\u00f6yl\u00fc","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck Department of Cardiac Surgery, , Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hulman","sequence":"additional","affiliation":[{"name":"Klinika Kardiochirurgie NUSCH , Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio","family":"Iacovoni","sequence":"additional","affiliation":[{"name":"Ospedale Papa Giovanni XIII , Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike S","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Erasmus MC-Sophia Children\u2019s Hospital Division of Pediatric Intensive Care, Department of Pediatric & Neonatal Intensive Care, , Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Loforte","sequence":"additional","affiliation":[{"name":"Sant\u2019Orsola University Hospital, IRCCS Bologna, Italy and University of Turin, Department of Surgical Sciences , Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Pace","family":"Napoleone","sequence":"additional","affiliation":[{"name":"Regina Margherita Children\u2019s Hospital Pediatric Cardiac Surgery Department, , Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Nemec","sequence":"additional","affiliation":[{"name":"Centre of cardiovascular surgery and transplantation , Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Netuka","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine (IKEM) , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00d6zbaran","sequence":"additional","affiliation":[{"name":"Ege University Hospital , Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Polo","sequence":"additional","affiliation":[{"name":"La Paz University Hospital , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Pya","sequence":"additional","affiliation":[{"name":"National Research Cardiac Surgery Center , Astana, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz","family":"Ramjankhan","sequence":"additional","affiliation":[{"name":"Utrecht University Medical Center , Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Sandica","sequence":"additional","affiliation":[{"name":"Clinic for Pediatric Cardiac Surgery and Congenital Heart Defects, Heart and Diabetes Centre North Rhine-Westphalia , Bad Oeynhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Sliwka","sequence":"additional","affiliation":[{"name":"Medical University of Silesia, Silesian Center for Heart Diseases Department of Cardiac Surgery, Transplantology and Vascular Surgery, , Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Stiller","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg-Bad Krozingen, University of Freiburg Department of Congenital Heart Defects and Pediatric Cardiology, , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kadner","sequence":"additional","affiliation":[{"name":"Bern University Hospital, University of Bern Center for Congenital Heart Disease, Department of Cardiac Surgery, Inselspital, , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Catholic University of Sacred Heart, Rome, Italy- Bambino Ges\u00f9 Children's Hospital, IRCCS Department of Cardiovascular and Pneumological Sciences, , Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Thiruchelvam","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital , London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Vienna Medical University , Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Berger","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum, der Charit\u00e9 Berlin Department of Congenital Heart Disease Pediatric Cardiology, , Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Davies","sequence":"additional","affiliation":[{"name":"Royal Children\u2019s Hospital Pediatric Cardiac Surgery Department, , Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Dashkevich","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Herzchirurgie Department of Cardiac Surgery, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoffer","family":"Stark","sequence":"additional","affiliation":[{"name":"Helsinki University Department of Cardiac Surgery, Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Meyns","sequence":"additional","affiliation":[{"name":"Katholieke Universiteit Leuven , Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo M M H","family":"de By","sequence":"additional","affiliation":[{"name":"EACTS House EUROMACS, , Windsor, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Miera","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum, der Charit\u00e9 Berlin Department of Congenital Heart Disease Pediatric Cardiology, , Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,19]]},"container-title":["European Journal of Cardio-Thoracic 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