{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:51:03Z","timestamp":1789469463534,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The objective of this study was to enhance the efficiency of aortic arch replacement through the development of a novel frozen elephant trunk (FET) prosthesis with an endovascular side branch for left subclavian artery (LSA) connection. After successful pre-clinical testing, the feasibility and safety of implementing this innovative prosthesis in human subjects were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Between September 2020 and September 2021, 4 patients (mean age 67) with conditions such as penetrating ulcer, non A\u2013non B aortic dissection and chronic arch aneurysm underwent surgery utilizing the customized device. Surgeries were performed under high moderate hypothermia (27\u00b0C), employing bilateral selective antegrade cerebral perfusion (SACP) and distal aortic perfusion. Anastomosis of the FET prosthesis with the aortic arch occurred in zone 1, followed by separate reimplantation of the left common carotid artery and the brachiocephalic artery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All patients were discharged in good clinical condition. The mean aortic cross-clamp, antegrade selective cerebral perfusion and distal aortic perfusion times were 111, 71 and 31\u2009min, respectively. Endovascular extension of the side branch for the LSA was required in all cases to prevent endoleak formation. One patient received a stent graft extension at the end of the operation, while 2 others underwent the procedure during their hospital stay. One patient was diagnosed with an endoleak at the first follow-up after 3\u2009months, and endoleak sealing was achieved via the brachial artery with an extension stent graft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Preliminary clinical outcomes suggest that the newly designed FET prosthesis shows promise in simplifying total arch replacement. These initial findings provide a foundation for planned clinical studies to further assess the effectiveness of this modified surgical hybrid graft, with particular attention to the length and diameter of the LSA sidearm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae302","type":"journal-article","created":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T18:47:05Z","timestamp":1723402025000},"source":"Crossref","is-referenced-by-count":13,"title":["First-in-men experience with a novel frozen elephant trunk prosthesis featuring an endovascular side branch for left subclavian artery connection"],"prefix":"10.1093","volume":"66","author":[{"given":"Sandra","family":"Folkmann","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Miosga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieluise","family":"Harrer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Trnka","sequence":"additional","affiliation":[{"name":"Department of Radiology and Interventional Radiology, Clinic Floridsdorf , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Eller","sequence":"additional","affiliation":[{"name":"Department of Radiology and Interventional Radiology, Clinic Floridsdorf , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Aschacher","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"},{"name":"Sigmund Freud Private University, Medical Faculty , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-9775","authenticated-orcid":false,"given":"Martin","family":"Czerny","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Surgery, University of Freiburg , Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"},{"name":"Sigmund Freud Private University, Medical Faculty , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-0268","authenticated-orcid":false,"given":"Martin","family":"Grabenw\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinic Floridsdorf , Vienna, Austria"},{"name":"Karl Landsteiner Institute of Cardiovascular Research , Vienna, Austria"},{"name":"Sigmund Freud Private University, Medical Faculty , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"2024082223015636200_ezae302-B1","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.3390\/jcm12124143","article-title":"Long-term results with 187 frozen elephant trunk procedures","volume":"12","author":"Arnold","year":"2023","journal-title":"JCM"},{"key":"2024082223015636200_ezae302-B2","author":"Murana"},{"key":"2024082223015636200_ezae302-B3","author":"Hoon"},{"key":"2024082223015636200_ezae302-B4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.21470\/1678-9741-2019-0220","article-title":"Which is the optimal frozen elephant trunk? A systematic review and meta-analysis of outcomes in 2161 patients undergoing thoracic aortic aneurysm surgery using E-vita OPEN PLUS hybrid stent graft versus ThoraflexTM hybrid prosthesis","volume":"35","author":"Harky","year":"2020","journal-title":"Braz J Cardiovasc Surg"},{"key":"2024082223015636200_ezae302-B5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jtcvs.2019.10.031","article-title":"Neurologic complications after the frozen elephant trunk procedure: a meta-analysis of more than 3000 patients","volume":"160","author":"Preventza","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2024082223015636200_ezae302-B6","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezad061","article-title":"Island remodelling in acute and chronic aortic dissection treated with frozen elephant trunk","volume":"63","author":"Dohle","year":"2023","journal-title":"Eur J Cardiothorac 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