{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:28Z","timestamp":1787008708010,"version":"build-2736575974"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-GSP-GG-24"],"award-info":[{"award-number":["2022-GSP-GG-24"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2023-GSP-GG-17"],"award-info":[{"award-number":["2023-GSP-GG-17"]}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7224341"],"award-info":[{"award-number":["7224341"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The optimal core temperature for hypothermic circulatory arrest during aortic arch surgery remains contentious. This study aims to evaluate patient outcomes under various temperatures within a large single-centre cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Between 2010 and 2018, patients diagnosed with type A aortic dissection underwent total arch replacement at Fuwai Hospital were enrolled. They were categorized into 4 groups: deep hypothermia group, low-moderate hypothermia group, high-moderate hypothermia group and mild hypothermia group. Clinical data were analysed to ascertain differences between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 1310 patients were included in this cohort. Operative mortality stood at 6.9% (90\/1310), with a higher incidence observed in the deep hypothermia group [29 (12.9%); 35 (6.9%); 21 (4.8%); 5 (3.4%); all adjusted P\u2009&amp;lt;\u20090.05]. Overall 10-year survival was 80.3%. Long-term outcomes did not significantly differ among the groups. Multivariable logistic analysis revealed a protective effect of higher core temperature on operative mortality (odds ratio 0.848, 95% confidence interval 0.766\u20130.939; P\u2009=\u20090.001). High-moderate hypothermia emerged as an independent protective factor for operative mortality (odds ratio 0.303, 95% confidence interval 0.126\u20130.727; P\u2009=\u20090.007). Multivariable Cox analysis did not detect an effect of hypothermic circulatory arrest on long-term survival (all P\u2009&amp;gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>High-moderate hypothermia (24.1\u201328\u00b0C) offers the most effective protection against surgical mortality and is therefore recommended. Different hypothermic circulatory arrest temperatures do not influence long-term survival or quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae311","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T11:24:12Z","timestamp":1723461852000},"source":"Crossref","is-referenced-by-count":14,"title":["The optimal degree of core temperature for hypothermic circulatory arrest in complex aortic arch surgery: results from 1310 patients"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-377X","authenticated-orcid":false,"given":"Kai","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 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