{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:05:43Z","timestamp":1760148343255,"version":"3.41.2"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Mitral valve regurgitation and left ventricular dysfunction are cardiovascular symptoms of Marfan syndrome. There is a paucity of information on tricuspid valve regurgitation and right ventricular function. In patients with Marfan syndrome, we looked at long-term changes in right ventricular function, tricuspid valve regurgitation and freedom from tricuspid valve repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Retrospective-observational single-centre analysis on right ventricular function and tricuspid regurgitation in Marfan patients who underwent surgery with cardioplegic arrest between 1995 and 2020. Patients were followed-up from 1st operation until death, with echocardiographic changes analysed longitudinally. Composite end point was tricuspid annular plane systolic excursion (TAPSE)\u2009\u226416 mm, severe tricuspid regurgitation or tricuspid repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The study included 135 patients who underwent 193 operations, 58 of those were reoperations in 40 patients. Median age at 1st operation was 35\u2009years [interquartile range (IQR) 26\u201346], median follow-up was 8.0\u2009years (IQR 3.0\u201316.0) and median time to 1st reoperation was 7.5\u2009years (IQR 3.4\u201312.5). The composite end point occurred in 81 observations in 40 patients, mostly as a recurrent event, after median 7.0\u2009years (IQR 1.0\u201313.0). Ten-year cumulative incidence for composite end point was 22.0% (95% CI 15\u201331) and 9.0% (95% CI 4.4\u201316) for new-onset TAPSE\u2009\u226416 mm, but no significant change in TAPSE was observed at 10\u2009years. Tricuspid regurgitation was associated with increased risk of annual progression (P\u2009&amp;lt;\u20090.001), but not clinically relevant at 10\u2009years. Actuarial 10-year survival was 91.1%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In Marfan patients with a history of cardiac surgery and subsequent reoperations, the right ventricular function remains stable. The incidence of severe tricuspid regurgitation and tricuspid repair remain low.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae313","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T16:06:37Z","timestamp":1723824397000},"source":"Crossref","is-referenced-by-count":1,"title":["Right ventricular function in Marfan patients remains stable despite multiple cardiac interventions"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-7985","authenticated-orcid":false,"given":"Maks","family":"Mihalj","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"},{"name":"Department of Advanced Cardiopulmonary Therapies and Transplantation, The University of Texas Health Science Center at Houston , Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-8884","authenticated-orcid":false,"given":"Maria","family":"Nucera","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Mosbahi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-1224","authenticated-orcid":false,"given":"Alan","family":"Haynes","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-6892","authenticated-orcid":false,"given":"Murat","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4061-4499","authenticated-orcid":false,"given":"Paul Philipp","family":"Heinisch","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"},{"name":"Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, Technical University , Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3311-4595","authenticated-orcid":false,"given":"Florian S","family":"Schoenhoff","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bern, University of Bern , Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"2024091720514355400_ezae313-B1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.athoracsur.2009.01.073","article-title":"Aortic root replacement in 372 Marfan patients: evolution of operative repair over 30 years","volume":"87","author":"Cameron","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"2024091720514355400_ezae313-B2","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. 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