{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:45:21Z","timestamp":1767905121346,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","award":["20220727"],"award-info":[{"award-number":["20220727"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Previous reports suggest that betablockers appear non-beneficial after surgical aortic valve replacement (SAVR). This study aims to clarify the associations between betablockers and long-term outcome after SAVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>All patients with isolated SAVR due to aortic stenosis in Sweden between 2006 and 2020, alive at 6 months after surgery, were included. Patients were identified in the SWEDEHEART registry, and records were merged with data from 3 other mandatory national registries. Association between dispensed betablockers and major adverse cardiovascular events (MACE) (all-cause mortality, myocardial infarction and stroke) was analyzed using Cox proportional hazards models, with time-updated data on medication and adjusted for age, sex and comorbidities at baseline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In total, 11\u00a0849 patients were included [median follow-up 5.4\u2009years (range 0\u201313.5)]. Betablockers were prescribed to 79.7% of patients at baseline, decreasing to 62.2% after 5\u2009years. Continuing treatment was associated with higher risk of MACE [adjusted hazard ratio 1.14 (95% confidence interval, CI 1.05\u20131.23)]. The association was consistent over subgroups based on age, sex and comorbidities except atrial fibrillation [hazard ratio (HR) 1.05 (95% CI 0.93\u20131.19)]. A sensitivity analysis including time-updated data on comorbidites attenuated the difference between the groups [HR 1.04 (95% CI 0.95\u20131.14, P\u2009=\u20090.33)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Treatment with betablockers did not appear to be associated with inferior long-term outcome after SAVR, when adjusting for new concomitant diseases. Thus, it is likely that it is the underlying cardiac diseases that are associated with MACE rather than betablocker treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae365","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T21:29:03Z","timestamp":1728336543000},"source":"Crossref","is-referenced-by-count":2,"title":["Betablockers and clinical outcome after surgical aortic valve replacement: a report from the SWEDEHEART registry"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-0860","authenticated-orcid":false,"given":"Emma C","family":"Hansson","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Sahlgrenska University Hospital , Gothenburg,","place":["Sweden"]},{"name":"Department of Molecular and Clinical Medicine, Institute of medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Martinsson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]},{"name":"Department of Cardiology, Sahlgrenska University Hospital , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Baranowska","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]},{"name":"Department of Cardiology, Sahlgrenska University Hospital , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotta","family":"T\u00f6rngren","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Sahlgrenska University Hospital , Gothenburg,","place":["Sweden"]},{"name":"Department of Molecular and Clinical Medicine, Institute of medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-6539","authenticated-orcid":false,"given":"Emily","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Surgery and Clinical Medicine, University of Turku , Turku,","place":["Finland"]},{"name":"Department of Surgery, Central Finland Hospital Nova , Jyv\u00e4skyl\u00e4,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-3749","authenticated-orcid":false,"given":"Erik","family":"Bj\u00f6rklund","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]},{"name":"Department of Medicine, South \u00c4lvsborg Hospital , Bor\u00e5s,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-9398","authenticated-orcid":false,"given":"Martin","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"2024101722065520900_ezae365-B1","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.jacc.2021.09.861","article-title":"Life expectancy after surgical aortic valve replacement","volume":"78","author":"Martinsson","year":"2021","journal-title":"J Am Coll 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