{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:31:37Z","timestamp":1787506297198,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>The study\u2019s primary outcome was to evaluate if post-transplant survival has improved over the last 2 decades. Secondary outcomes were the infant\u2019s waitlist mortality, waitlist time and identifying factors that affected the infant\u2019s survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>United Network for Organ Sharing (UNOS) database was queried for infants (age \u2264 1) who were listed for heart transplantation between 2000 and 2020. The years were divided into 3 eras (Era 1 2000\u20132006, Era 2 2007\u20132013 and Era 3 2014\u20132020). Non-parametric tests, Chi-Squared, Log-Rank test and Cox-Proportional hazard ratio were used for analysis (\u03b1\u2009=\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>4234 infants were listed for heart transplants between 2000 and 2020. At the time of listing, Infants in era 3 were more likely to be heavier [in kg (P\u2009&amp;lt;\u20090.001)] and had better renal function (P\u2009&amp;lt;\u20090.001). Additionally, they were less likely to be on dialysis (P\u2009&amp;lt;\u20090.001), on a ventilator (P\u2009&amp;lt;\u20090.001) and on extracorporeal membrane oxygenation (P\u2009&amp;lt;\u20090.001). There has been a significant increase in left ventricular assist device use (P\u2009&amp;lt;\u20090.001), though there was no difference in waitlist (0.154) or post-transplant survival (0.51). In all 3 eras, waitlist survival (P\u2009&amp;lt;\u20090.001) and post-transplant survival (P\u2009&amp;lt;\u20090.001) have improved significantly. Congenital heart disease and extracorporeal membrane oxygenation were associated with worse waitlist survival in all 3 eras (P\u2009&amp;lt;\u20090.05). Infants are now waiting longer on the waitlist (in days) (33 Era 1 vs 46 Era 2 vs 67 Era 3, P\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Infant heart transplant outcomes have improved, but they are now waiting longer on the waitlist. Further improvement in increasing the donor pool, expert consensus on listing strategies and donor utilization is needed to improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae384","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T23:25:11Z","timestamp":1729725911000},"source":"Crossref","is-referenced-by-count":1,"title":["Improvement in patient selection, management and outcomes in infant heart transplant from 2000 to 2020"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0772-236X","authenticated-orcid":false,"given":"Toyokazu","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine , Louisville, KY 40202,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimin","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine , Louisville, KY 40202,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Kozik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine , Louisville, KY 40202,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahaaldin","family":"Alsoufi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine , Louisville, KY 40202,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"2024110804555427500_ezae384-B1","doi-asserted-by":"crossref","first-page":"S300","DOI":"10.1016\/j.ajt.2023.02.008","article-title":"OPTN\/SRTR 2021 Annual Data Report: 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