{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:28Z","timestamp":1787008708170,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Safety, efficacy and durability are important considerations when selecting a bioprosthesis for aortic valve replacement (AVR). This study assessed 7-year clinical outcomes and haemodynamic performance of the Avalus bioprosthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Patients indicated for surgical AVR were enrolled in this prospective, nonrandomized trial, conducted across 39 sites globally. The primary end-point of this analysis was freedom from surgical explant or percutaneous valve-in-valve reintervention due to structural valve deterioration (SVD) at 7\u2009years of follow-up, determined using Kaplan\u2013Meier (KM) analysis. We also evaluated a composite end-point of SVD and\/or severe haemodynamic dysfunction requiring reintervention. Survival, valve-related safety events and haemodynamic performance were assessed. Deaths and safety events were adjudicated by an independent clinical events committee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 1132 patients underwent surgical AVR. Mean age was 70\u2009years; 854 patients (75%) were men. The mean STS risk of mortality was 2.0\u2009\u00b1\u20091.4%, and 659 patients (58%) had a New York Heart Association classification of I\/II. One or more concomitant procedures were performed in 577 patients (51%). At 7\u2009years, the Kaplan\u2013Meier rate of freedom from SVD\/severe haemodynamic dysfunction requiring reintervention was 1.2% (0.5\u20132.5%) with no cases adjudicated as SVD. The survival rate was 82.6% (79.5\u201385.0%). The KM event rate was 5.7% (4.3\u20137.7%) for reintervention, 6.3% (4.9\u20138.3%) for endocarditis and 0.4% (0.1\u20131.1%) for valve thrombosis. Mean aortic gradient, dimensionless velocity index and effective orifice area were 13.8\u2009\u00b1\u20095.9\u2009mmHg, 0.42\u2009\u00b1\u20090.09 and 1.99\u2009\u00b1\u20090.53 cm2, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This analysis demonstrated excellent durability of the Avalus valve with good clinical outcomes and stable haemodynamic performance through 7\u2009years of follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae414","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T15:22:02Z","timestamp":1731943322000},"source":"Crossref","is-referenced-by-count":9,"title":["Seven-year outcomes after surgical aortic valve replacement with a stented bovine pericardial bioprosthesis in over 1100 patients: a prospective multicentre 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