{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:07:29Z","timestamp":1790611649587,"version":"4.1.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/CRTF\/22\/24312"],"award-info":[{"award-number":["FS\/CRTF\/22\/24312"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Right ventricular-to-pulmonary artery coupling has been associated with outcomes in mitral regurgitation treated by transcatheter approaches. We evaluated right ventricular-to-pulmonary artery coupling as a predictor of survival and postoperative length of hospital stay (LOS) in patients with mitral regurgitation undergoing mitral valve surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this retrospective analysis (median follow-up: 5.8\u2009years), right ventricular-to-pulmonary artery coupling was quantified as the ratio of tricuspid annular plane systolic excursion to pulmonary artery systolic pressure (TAPSE\/PASP) using transthoracic echocardiography. Receiver operating characteristic curve analysis was used to determine the optimum cut-point of TAPSE\/PASP to predict all-cause mortality, and the study population was dichotomized according to this value. The primary end point was all-cause mortality. A secondary end point of LOS was also assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Out of 142 patients (median age: 67, female: 49%), 35 showed impaired coupling at baseline (TAPSE\/PASP \u22640.35). Patients with TAPSE\/PASP \u22640.35 had higher absolute mortality (37% vs 8%, P\u2009&amp;lt;\u20090.001) and longer LOS (7\u2009days vs 9\u2009days, P\u2009=\u20090.04). Kaplan\u2013Meier analysis revealed lower survival in patients with TAPSE\/PASP \u22640.35 (log-rank: P\u2009&amp;lt;\u20090.0001). In multivariable Cox regression, TAPSE\/PASP \u22640.35 was the most significant predictor of all-cause mortality (hazard ratio: 3.69, 95% confidence interval 1.31\u201310.1, P\u2009=\u20090.011), alongside chronic obstructive pulmonary disease and estimated glomerular filtration rate. TAPSE\/PASP \u22640.35 was associated with significantly increased LOS (\u03b2: 4.6, 95% confidence interval 0.66\u20138.5, P\u2009=\u20090.022) alongside left ventricular ejection fraction, mitral valve replacement and urgent operation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In mitral regurgitation patients undergoing mitral valve surgery, TAPSE\/PASP \u22640.35 is associated with increased mortality and LOS. Further validation is indicated in larger, prospective cohorts.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae421","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T16:58:00Z","timestamp":1732813080000},"source":"Crossref","is-referenced-by-count":8,"title":["Right ventricular to pulmonary arterial coupling as a predictor of survival in patients undergoing mitral valve surgery for mitral regurgitation"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-3060","authenticated-orcid":false,"given":"Omar","family":"Chehab","sequence":"first","affiliation":[{"name":"Department of Cardiology, St Thomas\u2019 Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1008-7966","authenticated-orcid":false,"given":"Edouard","family":"Long","sequence":"additional","affiliation":[{"name":"GKT School of Medical Education, King\u2019s College London , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1464-3109","authenticated-orcid":false,"given":"Vitaly","family":"Androshchuk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Thomas\u2019 Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1527-2263","authenticated-orcid":false,"given":"Harminder","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Thomas\u2019 Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Avlonitis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, St Thomas\u2019 Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, St Thomas\u2019 Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Lucchese","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, St Thomas\u2019 Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Thomas\u2019 Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-063X","authenticated-orcid":false,"given":"Simon","family":"Redwood","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Thomas\u2019 Hospital , 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