{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:59:10Z","timestamp":1792166350810,"version":"4.4.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Mesenteric malperfusion in acute aortic dissection remains a life-threatening complication with no standardized treatment strategy. This study aimed to describe and evaluate the outcomes of our integrated approach combining exploratory laparotomy, immediate mesenteric reperfusion, and central aortic repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We retrospectively reviewed patients with acute aortic dissection with a preoperative diagnosis of mesenteric malperfusion who were treated between August 2011 and November 2022. Our surgical approach was to establish cardiopulmonary bypass, followed by exploratory laparotomy with mesenteric artery flow assessment using Doppler ultrasound and direct perfusion if needed, central aortic repair, and subsequent mesenteric artery reconstruction. The primary end-point was the 30-day operative mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 217 patients with acute aortic dissection, 12 (5.5%) had mesenteric malperfusion on preoperative computed tomography. Ten patients underwent exploratory laparotomy, where Doppler ultrasonography revealed reduced mesenteric blood flow in five patients (2.3% of the total 217 patients). These patients underwent direct perfusion of the mesenteric artery via a side branch of the cardiopulmonary bypass circuit. Doppler ultrasound confirmed the restoration of mesenteric blood flow in all perfused patients. No bowel resections were required. The operative mortality in patients with mesenteric malperfusion was 20%. The causes of death were stroke (n\u2009=\u20091) and acute myocardial infarction (n\u2009=\u20091).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our integrated surgical strategy combining central aortic repair with concurrent exploratory laparotomy and immediate mesenteric perfusion demonstrated technical feasibility in managing mesenteric malperfusion during aortic repair. Further prospective studies with larger cohorts are warranted to validate these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezae452","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T21:44:57Z","timestamp":1734385497000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of direct mesenteric perfusion on malperfusion in acute type A aortic dissection repair"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6098-6809","authenticated-orcid":false,"given":"Ryota","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4078-8587","authenticated-orcid":false,"given":"Wataru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-8752","authenticated-orcid":false,"given":"Yoshiyuki","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshi","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9729-3020","authenticated-orcid":false,"given":"Tomonari","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikuni","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-6108","authenticated-orcid":false,"given":"Hideki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3854-5108","authenticated-orcid":false,"given":"Tomo","family":"Yoshizumi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-200X","authenticated-orcid":false,"given":"Sachie","family":"Terazawa","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , Nagoya,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-6833","authenticated-orcid":false,"given":"Yuji","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Nagoya University Graduate School of Medicine , 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