{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:06:56Z","timestamp":1788336416880,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Aortic valve repair\/sparing techniques have been established as effective treatments for aortic regurgitation and\/or aortic aneurysms. However, concerns remain regarding long-term durability, reproducibility and patient selection. This study aims to asses long-term clinical and echocardiographic outcomes, with a focus on aortic regurgitation grade and left ventricular ejection fraction evolution, in adults undergoing these procedures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Adult patients in the Heart Valve Society Aortic Valve Database, undergoing any aortic valve repair\/sparing technique were included. Time-to-event analyses were used for clinical outcomes and mixed-effects models for left ventricular ejection fraction and aortic regurgitation grade evolution. Techniques: isolated valve repair (group 1), ascending aortic replacement + valve repair (group 2), partial-root replacement \u00b1 valve repair (group 3) and valve-sparing root replacement \u00b1 valve repair (group 4).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Survival at 10 years was comparable to survival of the matched-general-population in each group. The 10-year cumulative incidence of reintervention was 19.5% [95% confidence interval (CI) 16.70\u201322.40%] in group 1 [including only double external annuloplasty in group 1; reintervention was not significantly different between techniques (P\u2009=\u20090.112)]; 13.8% (95% CI 10.10\u201318.10%) in group 2; 12.7% (95% CI 5.50\u201322.90%) in group 3; and 8.5% (95% CI 7.00\u201310.10%) in group 4 (P\u2009&amp;lt;\u20090.001). Severe preoperative aortic regurgitation grade [hazard ratio 1.95 (95% CI 1.19\u20133.21), P\u2009&amp;lt;\u20090.001] and left ventricular end-diastolic diameter [hazard ratio 1.03 (95% CI 1.00\u20131.05), P\u2009&amp;lt;\u20090.001] were predictive of reintervention in group 4; patch use was a predictor in all groups. The predicted left ventricular ejection fraction (%) initially increased (P\u2009&amp;lt;\u20090.001) and then stabilized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This study found that aortic valve repair\/sparing techniques provide viable and effective treatment options that should be considered for all eligible patients with aortic regurgitation and\/or aortic root\/ascending aortic aneurysms, given their potential to restore life expectancy and provide good haemodynamic outcomes with an acceptable hazard of reintervention.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf020","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T08:04:21Z","timestamp":1738051461000},"source":"Crossref","is-referenced-by-count":9,"title":["Aortic valve repair in adults: long-term clinical outcomes and echocardiographic evolution in different valve repair techniques"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0213-3651","authenticated-orcid":false,"given":"Francesco","family":"Zito","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Erasmus University Medical Centre , Rotterdam,","place":["The Netherlands"]},{"name":"Department of Cardiac Surgery, Sant'Andrea Hospital, Sapienza University of Rome , Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-8384","authenticated-orcid":false,"given":"Kevin M","family":"Veen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Erasmus University Medical Centre , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Melina","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Sant'Andrea Hospital, Sapienza University of Rome , Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-568X","authenticated-orcid":false,"given":"Emmanuel","family":"Lansac","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Sorbonne University, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Sch\u00e4fers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital Quir\u00f3nsalud Madrid , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-8099","authenticated-orcid":false,"given":"Laurent","family":"de Kerchove","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular & Thoracic Surgery, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain (UCL) , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-5623","authenticated-orcid":false,"given":"Johanna J M","family":"Takkenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Erasmus University Medical Centre , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5942-4727","authenticated-orcid":false,"given":"Jolanda","family":"Kluin","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Erasmus University Medical Centre , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4518-4332","authenticated-orcid":false,"given":"M Mostafa","family":"Mokhles","sequence":"additional","affiliation":[{"name":"Division of Heart and Lung Disease, Department of Cardiothoracic Surgery, Utrecht University Medical Center , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"2025030502265541900_ezaf020-B1","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jtcvs.2011.08.021","article-title":"Valve-sparing-root replacement with reimplantation technique to increase durability of bicuspid aortic valve repair","volume":"142","author":"de Kerchove","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025030502265541900_ezaf020-B2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jtcvs.2007.05.052","article-title":"Aortic root remodeling: 10-year experience with 274 patients","volume":"134","author":"Aicher","year":"2007","journal-title":"J Thorac Cardiovasc 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