{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:28:21Z","timestamp":1791390501635,"version":"4.3.3"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The aim of the study was to evaluate the outcomes of aortic valve repair techniques using cusp patch-plasty with CardioCel.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Between September 2014 and June 2021, a total of 167 patients underwent aortic valve reconstruction using cusp repair. In all patients CardioCel patch was used exclusively. An isolated cusp repair was performed in 117 patients (70%), while 50 patients with concomitant aortopathy needed a combined valve and root repair. Seventy-two patients (43%) presented with tricuspid valve. The mean age of the entire cohort was 54.3\u2009\u00b1\u200912.3\u2009years , 143 patients being males.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Early (30-day\/in-hospital) mortality was 0.6%. The survival at 2, 4, and 6\u2009years was 98.8%, 96.8%, and 95.7%, respectively. During the mean follow-up of 4.2\u2009\u00b1\u20091.7\u2009years (resulting in 697 patient-years), a relevant aortic insufficiency occurred in 10 patients (8 of them presenting with bicuspid valve). All the patients underwent a valve replacement, resulting in a 7.8\u2009\u00b1\u20092.5% cumulative risk of aortic valve reoperation and\/or insufficiency \u22653+ at 6\u2009years. The causes of reoperation were cusp tear at the suture line, progressive valve pathology, endocarditis, and unknown in 4, 4, 1, and 1, respectively. Degeneration and\/or calcification of the CardioCel has not been observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The intermediate results of aortic cusp repair using CardioCel are good. Anatomo-pathology of the aortic valve and quality of the cusps seem to be main reason of repair failure. Further investigations are needed to assess the long-term durability of CardioCel patch-plasty as an alternative to biological valve replacement in specific aortic valve pathologies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf049","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T16:48:46Z","timestamp":1739983726000},"source":"Crossref","is-referenced-by-count":5,"title":["Aortic valve reconstruction with Cardiocel: midterm results"],"prefix":"10.1093","author":[{"given":"Vadim P","family":"Irimie","sequence":"first","affiliation":[{"name":"Rh\u00f6n Clinic Campus Bad Neustadt Department of Cardiovascular Surgery, , Bad Neustadt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasim","family":"Nasra","sequence":"additional","affiliation":[{"name":"Rh\u00f6n Clinic Campus Bad Neustadt Department of Cardiovascular Surgery, , Bad Neustadt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Atieh","sequence":"additional","affiliation":[{"name":"Rh\u00f6n Clinic Campus Bad Neustadt Department of Cardiovascular Surgery, , Bad Neustadt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Ahmidou","sequence":"additional","affiliation":[{"name":"Rh\u00f6n Clinic Campus Bad Neustadt Department for Medical Statistics, , Bad Neustadt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Lehmkuhl\u00b3","sequence":"additional","affiliation":[{"name":"Rh\u00f6n Clinic Campus Bad Neustadt Department of Radiology, , Bad Neustadt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P","family":"Urbanski","sequence":"additional","affiliation":[{"name":"Rh\u00f6n Clinic Campus Bad Neustadt Department of Cardiovascular Surgery, , Bad Neustadt,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,19]]},"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezaf049\/61988705\/ezaf049.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezaf049\/61988705\/ezaf049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T09:16:06Z","timestamp":1740042966000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article\/doi\/10.1093\/ejcts\/ezaf049\/8024256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezaf049","relation":{},"ISSN":["1873-734X"],"issn-type":[{"value":"1873-734X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"article-number":"ezaf049"}}