{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:27:31Z","timestamp":1777987651848,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["29-A-3"],"award-info":[{"award-number":["29-A-3"]}]},{"name":"National Cancer Center Research and Development Fund","award":["2020-J-3"],"award-info":[{"award-number":["2020-J-3"]}]},{"name":"National Cancer Center Research and Development Fund","award":["2023-J-03"],"award-info":[{"award-number":["2023-J-03"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24ck0106833h0002"],"award-info":[{"award-number":["24ck0106833h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>This study aimed to compare the quality of mediastinal lymph node dissection (LND) during lobectomy for clinical stage I\u2013II non-small cell lung cancer (NSCLC) between video-assisted thoracic surgery (VATS) and open thoracotomy, using data from the Japan Clinical Oncology Group (JCOG) 1413 phase 3, randomized, controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>This analysis draws information from JCOG1413, comparing the efficacy of lobe-specific versus systematic LND with standardized LND protocols. A total of 1685 patients were included in this exploratory analysis (1251 VATSs and 434 open thoracotomies). Propensity score matching (PSM) ensured a balanced distribution of patient characteristics. The study\u2019s end-point was N2 upstaging, defined as the proportion of upstaging from clinical N0\u2013N1 to pathological N2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 1685 patients, 141 (8.3%) and 118 (7.0%) had pathological N1 and N2, respectively. The PSM yielded 852 patients (426 per group). The N2 upstaging proportions (7.8% [VATS] vs 7.3% [open], P = 0.795) and the influence of the lobectomy type on N2 upstaging were not significantly different between the 2 groups. The median number of N2 lymph nodes dissected per defined LND extent was similar (systematic: 13 in both groups, P = 0.236; lobe-specific: 7 in both groups, P = 0.720). Additionally, no significant difference in N2 upstaging was observed between hybrid and complete VATS groups (6.7% in both groups, P =. 982).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>This study found no significant differences in N2 upstaging proportions between the VATS and open thoracotomy groups of patients with clinical stage I\u2013II NSCLC. This suggests comparable quality of mediastinal LND in both surgical approaches.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CLINICAL TRIAL REGISTRATION<\/jats:title>\n                  <jats:p>This study is a sub-analysis of the JCOG1413 randomized controlled trial. The JCOG1413 trial is registered with the UMIN Clinical Trials Registry (UMIN0000025530).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf206","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T18:11:06Z","timestamp":1751047866000},"source":"Crossref","is-referenced-by-count":4,"title":["Quality comparison of mediastinal lymph node dissection between video-assisted thoracic surgery and open thoracotomy: a supplementary analysis of the phase 3 Japan Clinical Oncology Group 1413 trial"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-1709","authenticated-orcid":false,"given":"Norifumi","family":"Tsubokawa","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University Hospital , 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Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"JCOG Data Center\/Operations Office, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Yamagata Prefectural Central Hospital , Yamagata,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8928","authenticated-orcid":false,"given":"Takahiro","family":"Mimae","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University Hospital , Hiroshima,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-0691","authenticated-orcid":false,"given":"Tomohiro","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, National Cancer Center Hospital East , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-7133","authenticated-orcid":false,"given":"Tetsuya","family":"Isaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanagawa Cancer Center , Kanagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Isaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shizuoka Cancer Center Hospital , Shizuoka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aritoshi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Juntendo University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshige","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, Kansai Medical University Hospital , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery, Osaka City General Hospital , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Yotsukura","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Maniwa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Osaka International Cancer Institute , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Sekino","sequence":"additional","affiliation":[{"name":"JCOG Data Center\/Operations Office, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"JCOG Data Center\/Operations Office, National Cancer Center Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , 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