{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:04:28Z","timestamp":1792785868130,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["82473210"],"award-info":[{"award-number":["82473210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Shanghai","award":["24ZR1464400"],"award-info":[{"award-number":["24ZR1464400"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The efficacy of sub-lobectomy for clinical IA (tumours \u22642\u2009cm) lung squamous cell carcinoma with tumour spread through air spaces (STAS) remains unknown. This study compares long-term survival outcomes between sub-lobectomy and lobectomy, aiming to offer pivotal evidence for optimizing resection strategies for clinical IA STAS-positive squamous cell carcinoma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive clinical IA STAS-positive squamous cell carcinoma patients undergoing surgery between 2010 and 2020 at 7 high-volume institutions across 5 Chinese cities were retrospectively reviewed. The primary end-point was overall survival, and the secondary end-point was recurrence-free survival. Propensity-score matching was employed to mitigate selection bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 870 patients were included, and propensity-score matching yielded 476 and 238 cases in the lobe and sub-lobe groups, respectively. Over an estimated median follow-up of 6.51\u2009years, lobectomy significantly improved overall survival (hazard ratio [95% confidence interval]\u2009=\u20090.598 [0.447-0.761], P\u2009&amp;lt;\u2009.001) and recurrence-free survival (hazard ratio [95% confidence interval]\u2009=\u20090.572 [0.449-0.733], P\u2009&amp;lt;\u2009.001), and reduced postoperative mortality (30.7% vs 40.3%, P\u2009=\u2009.010) and recurrence (39.3% vs 55.0%, P\u2009&amp;lt;\u2009.001) incidences compared to sub-lobectomy. Further subgroup analysis revealed that lobectomy improved survival outcomes over sub-lobectomy in younger (age &amp;lt;70\u2009years) and clinical IA2 sub-cohorts, while the 2 approaches yielded comparable survival outcomes for elderly (age \u226570\u2009years) and clinical IA1 sub-cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lobectomy improved survival outcomes over sub-lobectomy for clinical IA STAS-positive squamous cell carcinoma and thus might be preferred for clinical IA squamous cell carcinoma patients with highly suspected STAS. The prognostic benefits of lobectomy may be discriminated by age and clinical stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf224","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T07:50:36Z","timestamp":1751529036000},"source":"Crossref","is-referenced-by-count":1,"title":["Lobectomy Versus Sub-lobectomy for Clinical Stage IA (\u22642\u2009cm) Lung Squamous Cell Carcinoma with Tumour Spread through Air Spaces: A Multi-Centre Retrospective Study"],"prefix":"10.1093","volume":"67","author":[{"given":"Hanbo","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University , Ningbo 315040,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The First Affiliated Hospital of Ningbo University , Ningbo 315020,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5252-9374","authenticated-orcid":false,"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Putuo District People\u2019s Hospital , Zhoushan 316100,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medicine, The First People\u2019s Hospital of Fuyang Hangzhou , Hangzhou 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Shaoyang University , Shaoyang 422001,","place":["China"]},{"name":"Department of Thoracic Surgery, The Central Hospital of Shaoyang , Shaoyang 422000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomo","family":"Ruan","sequence":"additional","affiliation":[{"name":"Hospital's Office, Wenzhou People\u2019s Hospital, Shanghai University , Wenzhou 325000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional Chinese and Western Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Shaoyang University , Shaoyang 422001,","place":["China"]},{"name":"Department of Thoracic Surgery, The Central Hospital of Shaoyang , Shaoyang 422000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 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