{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:28:27Z","timestamp":1791340107434,"version":"4.3.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Tumour location can affect clinicians\u2019 decisions regarding the surgical procedure, especially when choosing between lobectomy and segmentectomy. The biological behaviour of clinical stage I non-small cell lung cancer (NSCLC) may differ based on tumour location. We aimed to explore the biological behaviour of centrally located (CL) clinical stage I NSCLC and to identify which surgical procedure is more appropriate for such tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 719 patients who underwent curative operations for stage I NSCLC between April 2004 and December 2023. The biological behaviour of the tumours was analysed based on tumour location. Overall and recurrence-free survivals in patients who underwent lobectomy or more extensive procedures, including hilar and mediastinal lymph node dissection, were assessed based on tumour location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 124 (17.2%) and 595 (82.8%) patients were included in the CL and peripherally located groups, respectively. The CL group had a significantly higher standardized uptake value maximum on positron emission tomography\/computed tomography, a higher-grade adenocarcinoma subtype, and a higher frequency of lymph node metastasis than the peripherally located group. In multivariable analysis, CL and radiologically pure solid tumours (consolidation\/tumour ratio\u2009=\u20091) were significant factors for occult lymph node metastasis. No significant difference was observed in survival based on tumour location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Centrally located clinical stage I NSCLCs tend to be hypermetabolic and have a potential risk of lymph node metastasis. Lobectomy could be a better treatment option for CL clinical stage I NSCLC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf233","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T03:59:42Z","timestamp":1752292782000},"source":"Crossref","is-referenced-by-count":8,"title":["Lobectomy is the preferred choice rather than sublobar resection for centrally located clinical stage 1 non-small cell lung cancer"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2188-2837","authenticated-orcid":false,"given":"Satoshi","family":"Takamori","sequence":"first","affiliation":[{"name":"Department of Surgery II, Faculty of Medicine, Yamagata University , Yamagata 990-9585,","place":["Japan"]},{"name":"Department of Thoracic Surgery, Yamagata Prefectural Central Hospital , Yamagata 990-2292,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Yamagata Prefectural Central Hospital , Yamagata 990-2292,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgery II, Faculty of Medicine, Yamagata University , Yamagata 990-9585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-2470","authenticated-orcid":false,"given":"Jun","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Surgery II, Faculty of Medicine, Yamagata University , Yamagata 990-9585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Yamagata Prefectural Central Hospital , Yamagata 990-2292,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4087-635X","authenticated-orcid":false,"given":"Satoshi","family":"Shiono","sequence":"additional","affiliation":[{"name":"Department of Surgery II, Faculty of Medicine, Yamagata University , Yamagata 990-9585,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"2025073113214872000_ezaf233-B1","doi-asserted-by":"crossref","first-page":"ezac575","DOI":"10.1093\/ejcts\/ezac575","article-title":"Tumour location predicts occult N1 nodal metastasis in clinical stage I non\u2013small\u2013cell lung cancer","volume":"63","author":"Kawamoto","year":"2023","journal-title":"Eur J Cardiothorac 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