{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:14:46Z","timestamp":1758932086752,"version":"3.44.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to investigate differences in recurrence patterns between invasive mucinous adenocarcinoma and non-mucinous adenocarcinoma following surgical resection in patients with lung cancer without nodal or systemic metastasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively analysed the patients\u2019 data who underwent curative surgery for adenocarcinoma between 2011 and 2021. To balance clinical characteristics, 2:1 propensity score matching was performed. Recurrence patterns were classified as either intrapulmonary or extrapulmonary recurrence. Freedom from recurrence and cumulative incidence of recurrence were analysed to assess differences between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 4919 patients were included. After matching, 722 patients were non-mucinous group, and 368 patients were mucinous group. The mucinous group exhibited significantly higher freedom from recurrence (P\u2009=\u2009.033) compared to the non-mucinous group. The overall recurrence rate was lower in the mucinous group (8.4% vs 13.0%, P\u2009=\u2009.035). Although the incidence of intrapulmonary recurrence was comparable between groups (P\u2009=\u2009.50), extrapulmonary recurrence was significantly lower in the mucinous group (P\u2009=\u2009.02). Fine and Gray\u2019s multivariable analysis identified invasive mucinous histology as an independent factor associated with a lower risk of extrapulmonary recurrence (HR\u2009=\u20090.45; 95% CI, 0.22-0.89, P\u2009=\u2009.023). Visceral pleural invasion was a significant predictor for extrapulmonary recurrence (HR\u2009=\u20092.89; 95% CI, 1.37-6.09; P\u2009=\u2009.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The invasive mucinous adenocarcinoma group demonstrate better recurrence-free survival and a lower risk of extrapulmonary recurrence compared to the non-mucinous group following surgical resection. These findings highlight the need for further research aimed at developing tailored surveillance and treatment strategies based on tumour histological characteristics.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf282","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:17:47Z","timestamp":1756397867000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Lung: Distinct Recurrence Patterns of Mucinous and Non-mucinous Lung Adenocarcinoma After Surgery"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-1144","authenticated-orcid":false,"given":"Jun Oh","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Centre, University of Ulsan College of Medicine , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-7455","authenticated-orcid":false,"given":"Geun Dong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Centre, University of Ulsan College of Medicine , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-9289","authenticated-orcid":false,"given":"SeHoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Centre, University of Ulsan College of Medicine , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-7693","authenticated-orcid":false,"given":"Hyeong Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Centre, University of Ulsan College of Medicine , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2177-4876","authenticated-orcid":false,"given":"Yong-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Centre, University of Ulsan College of Medicine , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1984-0352","authenticated-orcid":false,"given":"Dong Kwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Asan Medical Centre, University of Ulsan College of Medicine , Seoul 05505,","place":["Republic of 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