{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:07:36Z","timestamp":1788786456767,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Melanie Munk Professorship in Aortic Biomechanical Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>How Marfan syndrome (MFS) translates to alterations in ex vivo biomechanical properties of aortic tissue is not well defined. We aimed to characterize the biomechanical properties of the aortic root and ascending aorta in MFS and compare them to properties of normal, dissected, and non-MFS aneurysmal aortas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Biaxial tensile and delamination testing were performed on aortic tissue from patients with MFS (root\u2009=\u200910, ascending\u2009=\u20096), aneurysms with bicuspid aortic valves (BAVs) (root\u2009=\u200919, ascending\u2009=\u200988), aneurysms with tricuspid aortic valves (root\u2009=\u200925, ascending\u2009=\u200990), type A dissections (ascending\u2009=\u200917), and normal aortas (root\u2009=\u200912, ascending\u2009=\u200928). Differences in energy loss, low strain modulus, and delamination strength were investigated between patient groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the aortic root, energy loss, low strain modulus, and delamination strength were not statistically different in MFS compared to all other groups. In the ascending aorta, delamination strength was lower in MFS than normal ascending aortas (31.9\u2009\u00b1\u20098.5 mN\/mm vs 57.1\u2009\u00b1\u200917.0 mN\/mm, P\u2009=\u20090.0003). The MFS group (0.071\u2009\u00b1\u20090.017) also had higher energy loss than normal (0.049\u2009\u00b1\u20090.011, P\u2009=\u20090.04), and lower low strain modulus (75.0\u2009\u00b1\u200911.0 kPa) than BAV (113.5\u2009\u00b1\u200933.6 kPa, P\u2009=\u20090.02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The root and ascending aorta in MFS proved to have distinct biomechanical characteristics compared to normal aortas and other risk groups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf293","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:41:03Z","timestamp":1756467663000},"source":"Crossref","is-referenced-by-count":5,"title":["Biomechanics of the Aortic Root and Ascending Aorta in Patients With Marfan Syndrome"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-5770","authenticated-orcid":false,"given":"Daniella","family":"Eliathamby","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto , Toronto, ON, M5S 3G9,","place":["Canada"]},{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research , Toronto, ON, M5G 1M1,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8340-5053","authenticated-orcid":false,"given":"Hayley W Y","family":"Yap","sequence":"additional","affiliation":[{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research , Toronto, ON, M5G 1M1,","place":["Canada"]},{"name":"Department of Mechanical and Industrial Engineering, University of Toronto , Toronto, ON, M5S 3G8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak","family":"Elbatarny","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Healthy Network , Toronto, ON, M5S 2C4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cillero Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Healthy Network , Toronto, ON, M5S 2C4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1892-6836","authenticated-orcid":false,"given":"Vrushali","family":"Guruji","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto , Toronto, ON, M5S 3G9,","place":["Canada"]},{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research , Toronto, ON, M5G 1M1,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Healthy Network , Toronto, ON, M5S 2C4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanzia","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Healthy Network , Toronto, ON, M5S 2C4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-2198","authenticated-orcid":false,"given":"Maral","family":"Ouzounian","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Healthy Network , Toronto, ON, M5S 2C4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7729-1772","authenticated-orcid":false,"given":"Craig A","family":"Simmons","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto , Toronto, ON, M5S 3G9,","place":["Canada"]},{"name":"Translational Biology and Engineering Program, Ted Rogers Center for Heart Research , Toronto, ON, M5G 1M1,","place":["Canada"]},{"name":"Department of Mechanical and Industrial Engineering, University of Toronto , Toronto, ON, M5S 3G8,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4079-2618","authenticated-orcid":false,"given":"Jennifer C -Y","family":"Chung","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, University of Toronto , Toronto, ON, M5S 3G9,","place":["Canada"]},{"name":"Department of Cardiovascular Surgery, University Healthy Network , Toronto, ON, M5S 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