{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:45:09Z","timestamp":1787510709561,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>VGT-309 (abenacianine) is being evaluated as an intraoperative molecular imaging (IMI) agent. This phase 2, open-label, dose-ranging study evaluated efficacy and safety in participants undergoing surgical resection of suspicious or proven cancer in the lung.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults who consented to participate in the study were assigned to treatment with VGT-309 at 0.05, 0.16, or 0.32 mg\/kg dose administered 2-6 or 12-36 hours presurgery. Intraoperative tumour fluorescence intensity and contrast were assessed to inform efficacy across dosing parameter. Ex vivo imaging of surgical specimens was performed before and after histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-seven participants received VGT-309. No lesions were visualized in participants receiving 0.05 mg\/kg or 0.16 mg\/kg administered 2-6 hours presurgery. Near-infrared (NIR) imaging after treatment with 0.16 mg\/kg 12-36 hours presurgery identified 3 of 4 lesions from 3 of 4 participants. Sixteen participants were administered 0.32 mg\/kg; 6 dosed 2-6 hours and 10 dosed 12-36 hours presurgery. IMI identified 6 of 7 lesions from 5 of 6 participants dosed 2-6 hours presurgery, while 8 of 11 lesions from 7 of 10 participants dosed 12-36 hours presurgery displayed intraoperative fluorescence. A single suspected unexpected serious adverse reaction of liver transaminitis resolved within 30 days. Otherwise, VGT-309 was safe and well tolerated in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results support the safety and efficacy of VGT-309 in identifying cancer in the lung with 0.16 mg\/kg day-before surgery dosing and 0.32 mg\/kg at either dosing schedule.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration Number<\/jats:title>\n                    <jats:p>ACTRN12621000301864.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf314","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:50:06Z","timestamp":1758369006000},"source":"Crossref","is-referenced-by-count":3,"title":["Phase 2 Dose-Ranging Trial of VGT-309 for Molecular Imaging of Cancer during Pulmonary Resection"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-9305","authenticated-orcid":false,"given":"Gavin M","family":"Wright","sequence":"first","affiliation":[{"name":"University of Melbourne Department of Surgery, St Vincent\u2019s Hospital , Melbourne, 3065,","place":["Australia"]},{"name":"Departments of Cardiothoracic Surgery & Surgical Oncology, St Vincent\u2019s Hospital , Melbourne, 3065,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J Matthew","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Vincent\u2019s Hospital , Melbourne, 3065,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M","family":"Mack","sequence":"additional","affiliation":[{"name":"Departments of Cardiothoracic Surgery & Surgical Oncology, St Vincent\u2019s Hospital , Melbourne, 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