{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:39:15Z","timestamp":1761093555075,"version":"build-2065373602"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Although a novel tumour-node-metastasis (TNM) classification (ninth edition) for N staging was recently proposed, there is still room for improvement. We assessed whether classifying N stage based on zones and the number of involved lymph node stations could better predict postoperative recurrence risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included 671 patients with pathological N1 or N2, M0 non-small-cell lung cancer (NSCLC). Lymph node zones were categorized as peripheral and hilar for N1 nodes, and upper mediastinal, lower mediastinal, aortopulmonary, and subcarinal for N2 nodes. The N category was subdivided according to the location and number of involved lymph node stations: N1a (single-zone\/single-station N1), N1b (multiple-zone\/multiple-station N1), N2a1 (single-zone\/single-station N2 without N1 involvement), N2a2 (single-zone\/single-station N2 with N1 involvement), and N2b (multiple-zone\/multiple-station N2, regardless of N1 involvement).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Recurrence-free survival (RFS) and cumulative incidence of recurrence (CIR) were stratified according to the pathological N1, N2a, and N2b groups based on the TNM (ninth edition) N descriptors. RFS (P\u2009&amp;lt;\u2009.001 for both) and CIR (P\u2009&amp;lt;\u2009.001 for both) were effectively stratified using both station- and zone-based classifications. Station- and zone-based N2a1 exhibited RFS (hazard ratio [HR], 1.04; 95% CI, 0.66-1.63 and HR, 1.12; 95% CI, 0.66-1.89, respectively) comparable to those of N1b. Considering station-based N2b, zone-based N2a2 (HR, 1.98; 95% CI, 0.69-5.66) and N2b (HR, 1.99; 95% CI, 0.72-5.52) tended to have worse RFS than zone-based N2a1.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both station- and zone-based nodal classifications effectively stratify recurrence risk and are good candidates for further N category stratification in NSCLC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf338","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:28:12Z","timestamp":1760016492000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrence Risk Stratification by Station- and Zone-Based Nodal Classification in Resected Non-Small Cell Lung Cancer"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-2443","authenticated-orcid":false,"given":"Atsushi","family":"Kamigaichi","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima 734-8551,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8928","authenticated-orcid":false,"given":"Takahiro","family":"Mimae","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima 734-8551,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-1709","authenticated-orcid":false,"given":"Norifumi","family":"Tsubokawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima 734-8551,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima 734-8551,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Medical University , Tokyo 160-0023,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanagawa Cancer Center , Yokohama, Kanagawa 241-8515,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-6093","authenticated-orcid":false,"given":"Hiroyuki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kanagawa Cancer Center , Yokohama, Kanagawa 241-8515,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Medical University , Tokyo 160-0023,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-6608","authenticated-orcid":false,"given":"Morihito","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Hiroshima University , Hiroshima 734-8551,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"2025102107511999000_ezaf338-B1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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