{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:48:30Z","timestamp":1782776910822,"version":"3.54.5"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Mediastinal lymph node staging is essential in the management of patients with non-small-cell lung cancer. According to the guideline of the European Society of Thoracic Surgery, invasive staging should be performed in selected patients. The outcome of invasive staging with video-assisted mediastinoscopic lymphadenectomy in patients with potentially respectable non-small-cell lung cancer is evaluated in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent invasive mediastinal staging by video-assisted mediastinoscopic lymphadenectomy between 2008 and 2019 received retrospective single-centre analysis. Patients were divided into 2 groups: one group met the guideline criteria for invasive staging, whereas the other group did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1640 patients were included in the study, 374 (22.8%) of whom had mediastinal lymph node metastases. N2 and N3 status were detected in 300 (18.2%) and 74 (4.5%) patients, respectively. The complication rate for the procedure was 4.8% (n\u2009=\u200979). False negative results were detected in 5 patients (2.2%). For the entire cohort, the sensitivity, specificity, negative predictive value, and accuracy were 98.68% (95% CI, 96.95%-99.57%), 100% (95% CI, 99.65%-100%), 99.53 (95% CI, 98.88%-99.8%), and 99.65% (95% CI, 99.19%-99.89%), respectively. In the guideline accordant-group, mediastinal metastases were detected in 370 out of 1463 cases (25.3%), whereas in the other-group, metastases were found in 4 out of 177 cases (2.3%), (P\u2009&amp;lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Video-assisted mediastinoscopic lymphadenectomy is a safe procedure with high sensitivity, specificity, negative predictive value, and accuracy. The guideline criteria for selecting patients who should be considered for invasive mediastinal staging are valid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical registration number<\/jats:title>\n                    <jats:p>Ethics committee of Medical Association Westphalia Lippe (2021-049-f-S).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf347","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T12:13:16Z","timestamp":1759925596000},"source":"Crossref","is-referenced-by-count":4,"title":["Value of Video-Assisted Mediastinal Lymphadenectomy in Mediastinal Staging in Non-Small-Cell Lung Cancer Patients"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7768-4522","authenticated-orcid":false,"given":"Katharina","family":"Greif","sequence":"first","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Evangelisches Krankenhaus Herne 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