{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T06:15:08Z","timestamp":1762755308568,"version":"build-2065373602"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluated whether preoperative selective digestive decontamination (SDD) with oral gentamicin reduces the incidence of postoperative infections in patients undergoing oesophagectomy for oesophageal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 64 patients who underwent oesophagectomy for oesophageal cancer. The primary outcome was clinically diagnosed postoperative infection. To address potential confounding and small-sample bias, a prespecified 5-variable model was fitted using Firth\u2019s penalized logistic regression. Model performance was assessed by area under the receiver operating characteristic curve (AUC), Brier score, and bootstrap-corrected calibration. Secondary outcomes included inflammatory markers, fever characteristics, antibiotic use, and perioperative recovery indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperative infections occurred in 4 of 27 (14.8%) patients in Group A and 12 of 37 (32.4%) in Group B (Fisher\u2019s exact P\u2009=\u2009.147). In the Firth model, preoperative oral gentamicin showed a non-significant trend towards lower infection risk (odds ratio [OR] 0.36, 95% confidence interval [CI], 0.09-1.28; P\u2009=\u2009.12). The model demonstrated acceptable discrimination (AUC 0.734) and good apparent calibration (Brier 0.144; calibration intercept 0, slope 1). Patients receiving gentamicin also had lower postoperative day 1 procalcitonin levels (median 0.14 vs 0.28 ng\/mL; P\u2009=\u2009.009), while other inflammatory markers and recovery indicators were similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative oral gentamicin-based SDD was associated with a numerically lower risk of postoperative infection and lower early inflammatory biomarkers, although the association did not reach statistical significance. Given the small sample size and single-centre design, these findings are exploratory and should be interpreted with caution. Larger multicentre randomized trials are needed to validate these preliminary observations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf352","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:59:17Z","timestamp":1760097557000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of Preoperative Selective Digestive Decontamination with Oral Gentamicin on Postoperative Infections after Esophagectomy"],"prefix":"10.1093","volume":"67","author":[{"given":"Hui","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University , Taizhou, Zhejiang, 317000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhitao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University , Taizhou, Zhejiang, 317000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Operating Room, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University , Taizhou, Zhejiang, 317000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University , Taizhou, Zhejiang, 317000,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8306-8312","authenticated-orcid":false,"given":"Yu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University , Taizhou, Zhejiang, 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