{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T06:11:00Z","timestamp":1762755060024,"version":"build-2065373602"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["24K18841"],"award-info":[{"award-number":["24K18841"]}]},{"name":"Practical Research for Innovative Cancer Control Fund of the Japan Agency for Medical Research and Development","award":["24ck0106973h0001","24ck0106974h0001"],"award-info":[{"award-number":["24ck0106973h0001","24ck0106974h0001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Segmentectomy for radiologically pure-solid non-small-cell lung cancer remains controversial due to the high rate of occult lymph node metastasis. Certain hilar lymph nodes (HLN) can be challenging to resect during segmentectomy, especially non-adjacent interlobar lymph node (non-aiLN) distant from the primary tumour. We aimed to elucidate whether HLN metastasis can be predicted more accurately in clinical stage IA pure-solid tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2009 and 2023, 693 consecutive patients with clinical stage IA pure-solid tumours who underwent lobectomy with HLN dissection were included. The frequencies of HLN and non-aiLN metastases were evaluated. Predictors of HLN metastasis were assessed using multivariable logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HLN and non-aiLN metastases were detected in 110 (15.9%) and 34 patients (4.9%), respectively. Multivariable logistic regression analysis revealed that carcinoembryonic antigen (CEA) level (P\u2009&amp;lt;\u2009.01), left side (P\u2009=\u2009.04), maximum standardized uptake value (SUVmax) (P\u2009&amp;lt;\u2009.01), and adenocarcinoma (P\u2009&amp;lt;\u2009.01) were independent predictors of HLN metastasis. Furthermore, in tumours with high SUVmax &amp;gt;5.0 and CEA &amp;gt;5.0 ng\/mL, based on the results of the multivariable logistic regression model, the frequency of HLN metastasis increased to 23.0% (28\/122). Additionally, 9 (32.1%) tumours had non-aiLN metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HLN and non-aiLN metastases were frequent among clinical stage IA pure-solid tumours, especially in those with SUVmax &amp;gt;5.0 and CEA &amp;gt;5.0 ng\/mL. HLN dissection during segmentectomy should be performed carefully in patients with clinical stage IA pure-solid tumours with high SUVmax and CEA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf361","type":"journal-article","created":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T12:46:40Z","timestamp":1761482800000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors and Patterns of Hilar Lymph Node Metastasis by Tumour Location in Clinical Stage IA Pure-solid Non-small-cell Lung Cancer"],"prefix":"10.1093","volume":"67","author":[{"given":"Takahiro","family":"Niimi","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Juntendo University School of Medicine , Bunkyoku, Tokyo 113-0013,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aritoshi","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Juntendo University School of Medicine , Bunkyoku, Tokyo 113-0013,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-0708","authenticated-orcid":false,"given":"Mariko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Juntendo University School of Medicine , Bunkyoku, Tokyo 113-0013,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-345X","authenticated-orcid":false,"given":"Takeshi","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Juntendo University School of Medicine , Bunkyoku, Tokyo 113-0013,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-6364","authenticated-orcid":false,"given":"Kazuya","family":"Takamochi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Juntendo University School of Medicine , Bunkyoku, Tokyo 113-0013,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Juntendo University School of Medicine , Bunkyoku, Tokyo 113-0013,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-2619","authenticated-orcid":false,"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Juntendo University School of Medicine , Bunkyoku, Tokyo 113-0013,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"2025111001085895500_ezaf361-B1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"2025111001085895500_ezaf361-B2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0022-5223(20)31797-9","article-title":"Radical lobectomy","volume":"39","author":"Cahan","year":"1960","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025111001085895500_ezaf361-B3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0003-4975(95)00537-U","article-title":"Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. 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