{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:21:59Z","timestamp":1789816919587,"version":"4.0.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The impact of donor-recipient age difference on survival after lung transplantation (LTx) remains unclear. This study investigates effects in different recipient age groups to optimize donor-recipient matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysing United Network for Organ Sharing (UNOS) data (2005-2015), we stratified adult first-time LTx recipients into 3 age strata (18-40, 40-60, 60-80 years). Donor-recipient age difference (\u0394 = donor age-recipient age) was classified into \u0394 \u2009&amp;lt;\u2009 0 and \u0394\u2009\u2265\u20090 groups; the 60-80 stratum was further divided into \u0394 &amp;lt; \u201310 and \u0394 \u2009&amp;lt;\u2009 0 to \u2264 \u221210 groups. Outcomes included 5-year (primary) and 10-year patient and graft survival, with subgroup analyses by underlying pulmonary disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\u0394 \u2009&amp;lt;\u2009 0 was associated with significantly better 5-year graft survival in the 18-40 and 40-60 strata (adjusted hazard ratio [HR]: 1.21 [1.02-1.44], P\u2009=\u2009.031 in 18-40; 1.19 [1.05-1.35], P\u2009=\u2009.006 in 40-60). Among recipients aged 60-80 (\u0394\u2009&amp;lt;\u20090 only), \u0394&amp;lt;\u221210 showed superior 5-year patient survival compared to \u0394 \u2009&amp;lt;\u2009 0 to \u2264 \u221210 (adjusted HR 1.23 [1.10-1.37], P\u2009&amp;lt;\u2009.001). Secondary analyses showed in 40-60, \u0394\u2009&amp;lt;\u20090 had better 10-year patient survival (adjusted HR: 1.14 [1.02-1.27], P\u2009=\u2009.017); and in 60-80, \u0394&amp;lt;\u221210 remained favourable (adjusted HR: 1.12 [1.02-1.23], P\u2009=\u2009.015). Subgroup analyses confirmed greater benefit younger donors in cystic fibrosis recipients aged 18-40 and 40-60, and idiopathic pulmonary fibrosis recipients aged 60-80.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Younger donors correlate with better intermediate- and long-term post-transplant survival, particularly for graft survival, supporting individualized preferential matching when clinically feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf372","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:59:22Z","timestamp":1762649962000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of Age Difference Between Donor and Recipient on Intermediate- and Long-Term Survival in Lung Transplant Recipients: A Cohort Study Based on Recipient Age Stratification"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1235-5502","authenticated-orcid":false,"given":"Wei","family":"He","sequence":"first","affiliation":[{"name":"First Clinical College, Guangzhou Medical University , Guangzhou, 510182,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]},{"name":"Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caikang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]},{"name":"Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]},{"name":"Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]},{"name":"Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Pan","sequence":"additional","affiliation":[{"name":"First Clinical College, Guangzhou Medical University , Guangzhou, 510182,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"He","sequence":"additional","affiliation":[{"name":"First Clinical College, Guangzhou Medical University , Guangzhou, 510182,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Lan","sequence":"additional","affiliation":[{"name":"First Clinical College, Guangzhou Medical University , Guangzhou, 510182,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]},{"name":"Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]},{"name":"Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-8326","authenticated-orcid":false,"given":"Jiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]},{"name":"Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease , Guangzhou 510120,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-6781","authenticated-orcid":false,"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, The First 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