{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:00:33Z","timestamp":1763762433427,"version":"3.45.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate results of thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysm (TAA) and to investigate outcomes based on adherence to manufacturer\u2019s instructions for use (IFUs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients treated with TEVAR in 4 tertiary hospitals between 2010 and 2021 were collected. Patients with connective tissue disorders, post-dissection TAAs, aortic coarctation and intramural haematomas were excluded. Both elective and urgent procedures were considered. Primary outcome was long-term survival. Secondary outcomes were: aortic-related reinterventions and late TEVAR failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 192 patients, 147 (76%) had endografts deployed inside IFU and 45 (24%) did not. Early outcomes were similar between groups with mortality rates of 6% inside IFU and 8.8% outside. Median follow-up was 36 months (interquartile range 20-63 months). Survival rate at 1, 3, and 5 years were 90%, 75%, and 61% for IFU group and 97%, 87%, and 66% for outside-IFU group (P = .55). Freedom from aortic-related reintervention at 1, 3, and 5 years were 94%, 87%, and 80% for IFU group and 88%, 78%, and 74% for outside IFU group (P = .04). TEVAR failure at 5 years occurred in 18 (13%) of inside IFU and 9 (22%) of outside IFU (P = .13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TEVAR is safe and effective in the long-term. Performing TEVAR outside IFU guidelines can still be acceptable but poses a higher risk of reintervention, especially for proximal landing zone violations. Close follow-up is essential to detect late failures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf376","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:20:28Z","timestamp":1761830428000},"source":"Crossref","is-referenced-by-count":0,"title":["Late Outcomes of Thoracic Endovascular Aneurysm Repair Outside Versus Inside Instruction for Use"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9825-031X","authenticated-orcid":false,"given":"Lorenzo","family":"Gibello","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgical Sciences, AOU Citt\u00e0 della Salute e della Scienza di Torino , Turin, 10126,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Piazza","sequence":"additional","affiliation":[{"name":"Vascular Endovascular Surgery Clinic, Padova University School of Medicine , Padua, 35100,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Gaggiano","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Unit, Mauriziano Hospital , Torino, 10128,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Maione","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, S. Croce e Carle Hospital , Cuneo, 12100,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Discalzi","sequence":"additional","affiliation":[{"name":"Division of Vascular Interventional Radiology, AOU Citt\u00e0 della Salute e della Scienza di Torino , Turin, 10126,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Squizzato","sequence":"additional","affiliation":[{"name":"Vascular Endovascular Surgery Clinic, Padova University School of Medicine , Padua, 35100,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Unit, Mauriziano Hospital , Torino, 10128,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Frola","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, S. 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