{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:20:53Z","timestamp":1790601653366,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"XVIVO Perfusion AB The Department of Pathophysiology and Transplantation"},{"DOI":"10.13039\/100012352","name":"University of Milan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italian Ministry of Education and Research (MUR): Dipartimenti di Eccellenza"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Lung transplantation is constrained by donor shortages and logistical challenges. Standard cold storage at 4\u2009\u00b0C limits metabolism but can cause cold-induced injury. Preservation at 10\u2009\u00b0C may better maintain cellular integrity and extend preservation time. This study evaluated the clinical safety and short-term effectiveness of lung graft preservation at 10\u2009\u00b0C within the Italian regulatory framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-centre, prospective comparative cohort study included adult recipients of bilateral lung transplantation. The intervention group received lungs transported on ice, preserved overnight at 10\u2009\u00b0C, and implanted the following morning. The control group included consecutive recipients with grafts preserved at 4\u2009\u00b0C and implanted immediately after arrival. The primary end-point was duration of postoperative mechanical ventilation. Secondary end-points were prolonged ventilation, grade III primary graft dysfunction, need for extracorporeal membrane oxygenation, intensive-care-unit stay, and survival. Inverse probability weighting adjusted for baseline imbalances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-one patients per group were analysed. The 10\u2009\u00b0C cohort had older donors and longer ischaemic times, yet outcomes were comparable: median ventilation 1 (1-3) days vs 2 (1-3) days (P\u2009=\u2009.167); grade III dysfunction 9.8% vs 21.6% (P\u2009=\u2009.102); extracorporeal support 19.6% vs 21.6% (P\u2009=\u2009.807); and median intensive-care-unit stay 4 (3-7) days in both groups (P\u2009=\u2009.824). Weighted analyses confirmed no significant differences. Survival was similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results support the short-term safety of moderate hypothermic preservation and its potential to improve surgical logistics by enabling daytime procedures. Further multicentre studies are required to confirm long-term outcomes and evaluate its broader clinical applicability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical registration number<\/jats:title>\n                    <jats:p>Milano2 Ethical Committee approved the study with protocol 749_2016bis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf390","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:57:28Z","timestamp":1762606648000},"source":"Crossref","is-referenced-by-count":6,"title":["Short-Term Outcomes After Lung Transplantation Using Grafts Preserved at 10\u202f\u00b0C: A Single-Centre Study"],"prefix":"10.1093","volume":"67","author":[{"given":"Riccardo","family":"Orlandi","sequence":"first","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]},{"name":"University of Milan , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4547-675X","authenticated-orcid":false,"given":"Margherita","family":"Brivio","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]},{"name":"University of Milan , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-3196","authenticated-orcid":false,"given":"Ilaria","family":"Righi","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-0449","authenticated-orcid":false,"given":"Davide","family":"Tosi","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Palleschi","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]},{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mendogni","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Damarco","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca\u2019 Granda-Ospedale Maggiore Policlinico , Milan, 20122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , 20122, 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