{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:04:41Z","timestamp":1790337881484,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"University Hospitals Leuven"},{"name":"Foundation Flanders","award":["G090922N and 18E2B24N"],"award-info":[{"award-number":["G090922N and 18E2B24N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cannabis-associated emphysema (CAE) involves bullous parenchymal destruction, often not considered for surgery due to the severe destruction and fragile tissue. It is affecting younger patients with limited smoking history, compared to typical emphysema. Given the heterogeneous pattern, lung volume reduction surgery (LVRS) may offer therapeutic benefit. This study explores the role of LVRS in patients with CAE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CAE patients were analyzed from a prospective collected database from August 2019 until December 2024. Chest computed tomography scan, lung function (forced expiratory volume in 1 second [FEV1], residual volume [RV], quality of life [COPD Assessment Test, CAT]) and operative outcomes were measured up to one-year postintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven patients (median 53 years (range, 40-70), all male) with 14 joint-years (3-168) underwent 11 LVRS procedures. Four patients experienced a previous pneumothorax. The median length of stay was 6.5 days (3-14), with a chest tube duration of 5.5 days (2-14). Air leaks occurred in 7 procedures (58%) for a median of 7 days (1-10), with prolonged air leak in 3 cases (27%). There was no mortality or readmission. Relative improvement at 6 to 12 months regarding FEV1 was +44% (36-108) and RV -43% (11-62). Six-minute walking distance and CAT improved with +72 m (-28 to 152) and 11 (0-17) points, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This preliminary single-center case series suggests that CAE may represent a suitable indication for properly performed LVRS, with favorable results attributable to its heterogeneous morphology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf415","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T12:53:48Z","timestamp":1763211228000},"source":"Crossref","is-referenced-by-count":1,"title":["Lung Volume Reduction Surgery for Cannabis-Associated Emphysema: Expanding Indication With Functional and Quality of Life Improvements"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-0314","authenticated-orcid":false,"given":"Christelle 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Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-4770","authenticated-orcid":false,"given":"Stephanie","family":"Everaerts","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism Laboratory of Pneumology and Thoracic Surgery (BREATHE), KU Leuven , 3000 Leuven,","place":["Belgium"]},{"name":"Department of Respiratory Diseases, University Hospitals Leuven , 3000 Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-8202","authenticated-orcid":false,"given":"Karin","family":"Klooster","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-3422","authenticated-orcid":false,"given":"Dirk-Jan","family":"Slebos","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen , 9713 GZ Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iseo","family":"Barb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven , 3000 Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-7228","authenticated-orcid":false,"given":"Iwein","family":"Gyselinck","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospitals Leuven , 3000 Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7324-7977","authenticated-orcid":false,"given":"Christophe","family":"Dooms","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism Laboratory of Pneumology and Thoracic Surgery (BREATHE), KU Leuven , 3000 Leuven,","place":["Belgium"]},{"name":"Department of Respiratory Diseases, University Hospitals Leuven , 3000 Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-227X","authenticated-orcid":false,"given":"Paul","family":"De Leyn","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven , 3000 Leuven,","place":["Belgium"]},{"name":"Department of Chronic Diseases and Metabolism Laboratory of Pneumology and Thoracic Surgery (BREATHE), KU Leuven , 3000 Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9961-7485","authenticated-orcid":false,"given":"Sofian","family":"Bouneb","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University Hospitals Leuven , 3000 Leuven,","place":["Belgium"]},{"name":"Department of Cardiovascular Sciences, Division of Anaesthesiology and Algology, KU Leuven , 3000 Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3641-7568","authenticated-orcid":false,"given":"Walter","family":"Weder","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Klinik Bethanien , 8044 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