{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T14:11:02Z","timestamp":1767708662778,"version":"3.48.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Jagiellonian University","award":["K\/ZDS\/004708"],"award-info":[{"award-number":["K\/ZDS\/004708"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether bilateral mediastinal lymphadenectomy (BML) affects the feasibility and invasiveness of lung resection in patients with lung cancer and its associated risks of adverse effects (AE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre randomized trial compared BML and systematic lymph node dissection (SLND). In all patients, standard anatomical lung resection was performed. In the BML group, the contralateral mediastinum was additionally dissected using the cervical approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 279 patients (135 BML and 144 SLND) were eligible for analysis; both groups had comparable basic clinical parameters. Both groups were comparable in terms of resection type (P\u2009=\u20090.193), blood loss (P\u2009=\u20090.927), and number of AE (P\u2009=\u20090.289). Compared with the SLND group, the BML group had a longer duration of surgery (440 minutes vs 133 minutes, P\u2009&amp;lt;\u20090.001) and a greater number of removed lymph nodes (45 vs 21, P\u2009&amp;lt;\u20090.001). Both groups were comparable in terms of AE (P\u2009=\u20090.171) and severe AE (P\u2009=\u20090.179). In the BML group, chest drainage duration and air leak duration were longer (8.3 vs 4.5 days, P\u2009&amp;lt;\u20090.001 and 1.9 vs 1.5 days, P\u2009=\u20090.026, respectively), the total volume of chest tube discharge was larger (1573 vs 907 mL, P\u2009&amp;lt;\u20090.001), and pain intensity on each of the 5 postoperative days was higher (P\u2009&amp;lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BML during pulmonary resection in patients with lung cancer is feasible and does not increase the risk of complications. It enables significantly more extensive lymphadenectomy but is associated with a longer duration of surgery and increased air leak duration, chest tube drainage, and pain intensity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf457","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:54:33Z","timestamp":1765976073000},"source":"Crossref","is-referenced-by-count":0,"title":["Randomized Study on Bilateral Versus Standard Mediastinal Lymphadenectomy in Patients With Lung Cancer\u2014Early Results and Safety Analysis"],"prefix":"10.1093","volume":"68","author":[{"given":"Jaros\u0142aw","family":"Ku\u017cd\u017ca\u0142","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Jagiellonian University Collegium Medicum , Krak\u00f3w,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sun Yat-Sen University , Guangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akif","family":"Turna","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Cerrahpasa Medical School, Istanbul University-Cerrahpasa , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Szadurski","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, John Paul II Hospital , Krak\u00f3w,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sun Yat-Sen University , Guangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gizem Ozcibik","family":"Is\u0131k","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Cerrahpasa Medical School, Istanbul University-Cerrahpasa , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander","family":"Galas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Jagiellonian University Collegium Medicum , Krak\u00f3w,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sun Yat-Sen University , Guangzhou,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve Ekinci","family":"Fidan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Koco\u0144","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Jagiellonian University Collegium Medicum , Krak\u00f3w,","place":["Poland"]},{"name":"Department of Thoracic Surgery, John Paul II Hospital , Krak\u00f3w,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"2026010609071564300_ezaf457-B1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0096-5588(20)31234-4","article-title":"Radical pneumonectomy","volume":"22","author":"Cahan","year":"1951","journal-title":"J Thorac Surg"},{"key":"2026010609071564300_ezaf457-B2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0022-5223(20)31797-9","article-title":"Radical lobectomy","volume":"39","author":"Cahan","year":"1960","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026010609071564300_ezaf457-B3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0022-5223(19)34555-6","article-title":"Direct lymphatic drainage of lung segments to the mediastinal nodes. 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