{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T21:50:11Z","timestamp":1768168211956,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Synapse Biomedical, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Prolonged mechanical ventilation after cardiac surgery occurs in 15% of patients and significantly increases morbidity and mortality. We investigated the potential benefits of diaphragm pacing following cardiac surgeries to decrease ventilator burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized controlled pilot study was conducted at 2 centres using diaphragm pacing in patients undergoing open cardiac surgery by median sternotomy. Enrolled patients had at least one pre-identified high-risk criterion for requiring prolonged ventilation. Diaphragm pacing was initiated postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-six patients were randomized into Standard of Care (34) and Treatment (32) groups. This study provides evidence that diaphragm pacing may reduce mechanical ventilation time and improve weaning success prior to 24 hours post-operatively. Treated patients had a total of 246 hours of mechanical ventilation compared to 670 hours for the standard of care group. Treatment group patients were more likely to be successfully weaned at 12 hours post-operatively, 83% compared to 65%, which represented an 18% absolute and 52% relative risk reduction. For the subset of 14 Treatment and 19 Standard of Care patients that required ventilation beyond 6 hours, those receiving diaphragm pacing had a reduced median time on ventilation: 8.3 hours (95% CI 7.1-12.5) compared to 16.8 hours (95% CI 8.1-23.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diaphragm pacing may reduce the time on mechanical ventilation following cardiac surgery in patients at risk of prolonged ventilation. These results will inform the design of a prospective, pivotal, randomized controlled trial to assess the ability of diaphragm pacing to reduce ventilator burden in high-risk cardiac surgery patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical registration number<\/jats:title>\n                    <jats:p>Clinicaltrials.gov: NCT 04899856, NCT 05404477<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezaf472","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T12:54:07Z","timestamp":1766062447000},"source":"Crossref","is-referenced-by-count":0,"title":["Multicentre Study of Diaphragm Pacing in High-Risk Cardiac Surgery to Decrease Postoperative Mechanical Ventilation"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-5022","authenticated-orcid":false,"given":"Charles-Henri","family":"David","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Chirurgie Thoracique et Cardiovasculaire, l\u2019Institut du thorax , Nantes F-44000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mickael","family":"Vourc\u2019h","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital La\u00ebnnec , Nantes F-44000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-0348","authenticated-orcid":false,"given":"Guillaume","family":"Guimbretiere","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Chirurgie Thoracique et Cardiovasculaire, l\u2019Institut du thorax , Nantes F-44000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Mugniot","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Chirurgie Thoracique et Cardiovasculaire, l\u2019Institut du thorax , Nantes F-44000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Lacoste","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service de Chirurgie Thoracique et Cardiovasculaire, l\u2019Institut du thorax , Nantes F-44000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Cadiet","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital La\u00ebnnec , Nantes F-44000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-3982","authenticated-orcid":false,"given":"Bertrand","family":"Rozec","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, Service d\u2019Anesth\u00e9sie-R\u00e9animation, H\u00f4pital La\u00ebnnec , Nantes F-44000,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Hospitals Cleveland Medical Center , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery and Heart and Vascular Center, Yale New Haven Hospital, Yale School of Medicine , New Haven, CT 06519,","place":["United 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