{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:53:05Z","timestamp":1774313585426,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"European Society of Thoracic Surgeons Biology Club Fellowship 2020"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed at identifying predictors of loco-regional recurrence in patients who underwent non-anatomical (wedge) resection(s) of lung metastases at 15 European centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicentre retrospective analysis of patients \u226518 years who underwent curative-intent wedge resection(s) of lung metastases (January 2010-December 2018). Exclusion criteria were: previous metastasectomy, non-curative intent, incomplete (R1\/R2) resection, and lack of data concerning recurrence. Loco-regional recurrence was defined as any recurrence occurring in the lungs, hilar-mediastinal lymph nodes, and\/or pleurae. Subset analyses were conducted on patients with a solitary metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 588 patients were included (56.1% adenocarcinoma). Five-year overall survival was 63.9% (95% CI\u2009=\u200960.43; 67.18). Five-year loco-regional recurrence rate was 47.7% (95% CI\u2009=\u200942.8; 52.4). Mean resection margin width was 6.8 mm (IQR\u2009=\u20092.0-10.0). 422 patients (71.8%) underwent a single wedge resection. In the total sample, univariable Cox regression showed that primary tumour site (P\u2009=\u2009.0003), primary tumour histology (P\u2009=\u2009.0027), resection margin width (P\u2009=\u2009.0060), log(margin-to-tumour size ratio) (P\u2009=\u2009.0022), and number of metastases (P\u2009&amp;lt;\u2009.0001) were significantly associated with loco-regional recurrence. In patients with a solitary metastasis, univariable analyses showed that primary tumour site (P\u2009=\u2009.0150), primary tumour histology (P\u2009=\u2009.0248), and log(margin-to-tumour size ratio) (P\u2009=\u2009.0355) were significantly associated with loco-regional recurrence. In multivariable analyses (solitary metastasis group), primary squamous-cell carcinoma histology was significantly associated with loco-regional recurrence (P\u2009=\u2009.0023). Resection margin width and log(margin-to-tumour size ratio) did not significantly affect loco-regional recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Loco-regional recurrence after pulmonary metastasectomy seems to be correlated with primary tumour histology and the number of metastases. Further studies are needed to clarify the role of size-adjusted margin parameters in preventing recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezag003","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:24:19Z","timestamp":1767443059000},"source":"Crossref","is-referenced-by-count":1,"title":["Predictors of Loco-Regional Recurrence After Pulmonary Non-Anatomical Metastasectomy: A Multicentre Retrospective Analysis"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-3998","authenticated-orcid":false,"given":"Elena","family":"Prisciandaro","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (HUB) , Brussels,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bertolaccini","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, 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