{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:32:10Z","timestamp":1783582330953,"version":"3.55.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Transcatheter mitral valve implantation (TMVI) is increasingly used in failed bioprostheses and annuloplasty rings as a less invasive alternative to redo-surgery in selected patients, with promising results. This retrospective single-centre study aims to provide additional insight into clinical outcomes and its determinants following TMVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of all TMVI procedures (n\u2009=\u200988) performed between February 2014 and June 2024 were retrospectively analysed. The primary end-points were 1-year mortality and the Mitral Valve Academic Research Consortium (MVARC) composite end-points. Secondary outcomes included complications and echocardiographic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, in-hospital, 30-day, and 1-year mortality rates were 6.8%, 5.8%, and 16.5%, respectively. No significant differences were observed between transseptal and transapical approach (20.0 vs 13.2%, P\u2009=\u2009.439) or between valve-in-valve and valve-in-ring procedure (16.3 vs 18.2%, P\u2009=\u2009.828). At 1-year follow-up, only one patient presented with mitral regurgitation \u2265 grade 2. However, a post-procedural mean pressure gradient (MPG) \u22655 mm Hg was observed in 51 patients (58%). In multivariate analysis, higher post-procedural MPG was associated with increased mortality risk (P\u2009=\u2009.047; hazard ratio [HR]\u2009=\u20091.23; 95% CI, 1.00-1.51), whereas technical success was associated with reduced mortality risk (P\u2009=\u2009.014; HR\u2009=\u20090.12; 95% CI, 0.02-0.65).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transcatheter mitral valve implantation provided acceptable mid-term mortality irrespective of procedure type and access route, with excellent technical success. Furthermore, mid-term follow-up showed near-complete elimination of mitral regurgitation. However, a high rate of post-procedural relevant mitral stenosis was observed, which may have an impact on mortality. In the light of the anticipated increase in TMVI procedures, we advocate for larger prospective studies to investigate the long-term determinants of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>As this study was retrospective and based on previously collected clinical data, clinical trial registration was not required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezag031","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:28:10Z","timestamp":1768307290000},"source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of Transcatheter Mitral Valve Implantation for Failed Bioprostheses and Annuloplasty Rings"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0702-6194","authenticated-orcid":false,"given":"Chong Bin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Structural Heart Interventions Program (SHIP) , Berlin 13353,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9361-8817","authenticated-orcid":false,"given":"Victor","family":"Schweiger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Schwarzkopf","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Structural Heart Interventions Program (SHIP) , Berlin 13353,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin , Berlin 10785,","place":["Germany"]},{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6201-1600","authenticated-orcid":false,"given":"Marian","family":"Kukucka","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Structural Heart Interventions Program (SHIP) , Berlin 13353,","place":["Germany"]},{"name":"Department of Cardiac Anaesthesiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Structural Heart Interventions Program (SHIP) , Berlin 13353,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin , Berlin 10785,","place":["Germany"]},{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-8620","authenticated-orcid":false,"given":"Volkmar","family":"Falk","sequence":"additional","affiliation":[{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Structural Heart Interventions Program (SHIP) , Berlin 13353,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin , Berlin 10785,","place":["Germany"]},{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]},{"name":"Department Health Sciences and Technology, Translational Cardiovascular Technology, ETH Zurich , Zurich 8093,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1909-4329","authenticated-orcid":false,"given":"Henryk","family":"Dreger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Structural Heart Interventions Program (SHIP) , Berlin 13353,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin , Berlin 10785,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9 (DHZC) , Berlin 13353,","place":["Germany"]},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin , Berlin 10117,","place":["Germany"]},{"name":"Deutsches Herzzentrum der Charit\u00e9, Structural Heart Interventions Program (SHIP) , Berlin 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